O67502

PR
Gene name
trpA
Protein name
Tryptophan synthase alpha chain
Names
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_1548
EC number
4.2.1.20: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-42 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for O67502

Entry ID Method Resolution Chain Position Source
2EKC X-ray 200 A A/B 1-262 PDB
AF-O67502-F1 Predicted AlphaFoldDB

No variants for O67502

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O67502

No associated diseases with O67502

2 regional properties for O67502

Type Name Position InterPro Accession
domain Tryptophan synthase beta chain-like, PALP domain 50 - 375 IPR001926
conserved_site Tryptophan synthase, beta chain, conserved site 78 - 92 IPR006653

Functions

Description
EC Number 4.2.1.20 Hydro-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

1 GO annotations of molecular function

Name Definition
tryptophan synthase activity Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O.

1 GO annotations of biological process

Name Definition
tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGRISDKFTE LKEKREKALV SYLMVGYPDY ETSLKAFKEV LKNGTDILEI GFPFSDPVAD
70 80 90 100 110 120
GPTIQVAHEV ALKNGIRFED VLELSETLRK EFPDIPFLLM TYYNPIFRIG LEKFCRLSRE
130 140 150 160 170 180
KGIDGFIVPD LPPEEAEELK AVMKKYVLSF VPLGAPTSTR KRIKLICEAA DEMTYFVSVT
190 200 210 220 230 240
GTTGAREKLP YERIKKKVEE YRELCDKPVV VGFGVSKKEH AREIGSFADG VVVGSALVKL
250 260
AGQKKIEDLG NLVKELKEGL RE