O67463
Gene name |
trmD (aq_1489) |
Protein name |
tRNA (guanine-N(1)-)-methyltransferase |
Names |
M1G-methyltransferase, tRNA [GM37] methyltransferase |
Species |
Aquifex aeolicus (strain VF5) |
KEGG Pathway |
aae:aq_1489 |
EC number |
2.1.1.228: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for O67463
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1OY5 | X-ray | 260 A | A/B/C | 1-257 | PDB |
| AF-O67463-F1 | Predicted | AlphaFoldDB |
No variants for O67463
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O67463 | |||||
No associated diseases with O67463
1 regional properties for O67463
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | tRNA methyltransferase TRMD/TRM10-type domain | 28 - 222 | IPR016009 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.228 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| tRNA (guanine(37)-N(1))-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA N1-guanine methylation | The process whereby a guanine in tRNA is methylated at position N1 of the guanine. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSNPLRFFV | LTIFPHIISC | YSEYGIVKQA | IKKGKVEVYP | IDLREFAPKG | QVDDVPYGGL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PGMVLKPEPI | YEAYDYVVEN | YGKPFVLITE | PWGEKLNQKL | VNELSKKERI | MIICGRYEGV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DERVKKIVDM | EISLGDFILS | GGEIVALAVI | DAVSRVLPGV | LSEPQSIQED | SFQNRWLGYP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VYTRPREYRG | MKVPEELLSG | HHKLIELWKL | WHRIENTVKK | RPDLIPKDLT | ELEKDILNSI |
| 250 | |||||
| LSGKSFKEWL | KEHKHLL |