O67411
Gene name |
valS |
Protein name |
Valine--tRNA ligase |
Names |
Valyl-tRNA synthetase, ValRS |
Species |
Aquifex aeolicus (strain VF5) |
KEGG Pathway |
aae:aq_1413 |
EC number |
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O67411
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O67411-F1 | Predicted | AlphaFoldDB |
No variants for O67411
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O67411 | |||||
No associated diseases with O67411
7 regional properties for O67411
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Aminoacyl-tRNA synthetase, class I, conserved site | 43 - 54 | IPR001412 |
| domain | Aminoacyl-tRNA synthetase, class Ia | 15 - 394 | IPR002300-1 |
| domain | Aminoacyl-tRNA synthetase, class Ia | 546 - 603 | IPR002300-2 |
| domain | Aminoacyl-tRNA synthetase, class Ia | 701 - 839 | IPR002300-3 |
| domain | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding | 883 - 1040 | IPR013155 |
| domain | Valyl-tRNA synthetase, tRNA-binding arm | 1099 - 1163 | IPR019499 |
| domain | Valyl tRNA synthetase, anticodon-binding domain | 839 - 985 | IPR033705 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.9 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aminoacyl-tRNA editing activity | The hydrolysis of an incorrectly aminoacylated tRNA. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| valine-tRNA ligase activity | Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| valyl-tRNA aminoacylation | The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEIKEYNPRE | IEEKWSRYWI | EKALYHVEKP | DKRKKFSVVI | PPPNVTGSLH | MGHALNATLQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DVIVRWQRMR | GRECVWVPGF | DHAGIATQYV | VEKQLAKEGK | SRLELGREEF | LKKVWEWVPK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SRNAIRTQLT | KLGVSVDWKR | ERFTLDEGFS | RAVRKAFRTL | FEEGLIYRAE | YIVNWCPNDR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TALSDLEVEY | EEEKGSLWYI | KYPIVDENGK | DTGEFITVAT | TRPETMLGDT | AVAVNPNDDR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YKHLVGKRAR | LPLVNWERKD | LRGNSVSNLI | PIIADERVKM | DFGTGAVKIT | PAHDPLDFEI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GKTHDLPFVR | VIDETGRMNE | NAGDFAGMDR | YEAREAIVAK | LREDELLEKE | EEITHSVGHC |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YRCKTVIEPM | VSVQWFVKVS | DPRIKDISIK | VVEEGIKERE | EKELFVQLAQ | VEELSVVIPL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KEEGRHKIVV | VLDKTAKFLV | GKREGELAYI | YYPKGDERTL | EFAKRLAEEF | KDYEFMVAYE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GLPKIVVMGN | EQLVEPGSYL | FVYDGKKLDL | YKLEGEKPKF | LKTLGKGEAD | LEVTQKSIQI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KPERIKKVEE | REKRVKFIPE | HWKKFYLDWM | YNLKDWCISR | QIWWGHRIPV | WYCKDCGNVN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VFTDDDFDRA | HDKIIFNLIA | DGKIDQEFTP | EEVEKVLKSP | HFVHPEMTVL | DFYKKFVFHR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YYNMDITADS | LRLLFTQDMN | PMAMLTPGVS | TRNIYKYDSQ | KKKWKMVLRC | KKCGSENLEQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ERDVLDTWFS | SALWPFGVFG | WPESTEDLKN | LYPTDLLVTG | FDIIFFWVAR | MIMMGTHFMK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DIPFYDVYVH | ALVRDKYGRK | MSKTIGNVID | PLDIIERYGA | DALRFTLAIL | TVQGRDIKLA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| EEKFEGYKHF | ANKIWNAARY | VLMNTPEDFI | ARIPYMAPLK | PEDKWIITKL | NETAEEVNKA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LENYQYSQAA | HAIYEFFWSD | YCDWYIEFTK | ERIYKKAPED | NEEEKAKVEN | ERTTALYTLH |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| YVLEKALRIL | HPFMPYITEE | LWHKLPNAEG | ESISLAEFPQ | KNEDEIYEED | KQKVERLKEI |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ISAIRAIRSD | LQIKPSEKIK | ASFKTESEFS | RRVIQEFKNH | ILNLAKLESF | EEVSQRPQNT |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| VATFSKDTEI | YVHIEGHVDL | DKLIQSYEKK | REKLLKELER | VNKKLSNENF | LKKAPVEVVE |
| 1150 | 1160 | ||||
| KEKQIKEELE | NDLKKVEEIL | KVLRS |