O67337

PR
Gene name
nuoI
Protein name
NADH-quinone oxidoreductase subunit I
Names
NADH dehydrogenase I subunit I, NDH-1 subunit I
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_1317
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

140-201 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for O67337

Entry ID Method Resolution Chain Position Source
7Q5Y X-ray 270 A D/J/P/V 1-201 PDB
AF-O67337-F1 Predicted AlphaFoldDB

No variants for O67337

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O67337

No associated diseases with O67337

2 regional properties for O67337

Type Name Position InterPro Accession
domain 4Fe-4S ferredoxin-type, iron-sulphur binding domain 78 - 147 IPR017896
conserved_site 4Fe-4S ferredoxin, iron-sulphur binding, conserved site 127 - 138 IPR017900

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane respiratory chain complex I A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species.

4 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
iron ion binding Binding to an iron (Fe) ion.
NADH dehydrogenase (quinone) activity Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol.
quinone binding Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds.

1 GO annotations of biological process

Name Definition
aerobic respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGVKKLSRKD YLNILESILF IDFLKGLSVT LKNLLRRPIT TEYPKEKLTP PKRFRGAHGH
70 80 90 100 110 120
YVWDGTEPDS LKAIEKFMSY EKAKSRCVAC YMCQTACPMP TLFRIEAVQL PNGKKKVVRF
130 140 150 160 170 180
DMNLLNCLFC GLCVDACPVG CLTMTDIFEL ANYSRRNEVL RMEDLEKFAI DFKQRRGNEP
190 200
DRIWPNDEER EKLWGKIEWS G