O67323

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_1293
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

384-519 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for O67323

Entry ID Method Resolution Chain Position Source
1RIQ X-ray 214 A A 1-454 PDB
1YFR X-ray 215 A A/B 1-454 PDB
1YFS X-ray 208 A A/B 1-454 PDB
1YFT X-ray 223 A A 1-454 PDB
1YGB X-ray 248 A A 1-454 PDB
3G98 X-ray 185 A A/B 758-867 PDB
3HTZ X-ray 250 A A 2-454 PDB
AF-O67323-F1 Predicted AlphaFoldDB

No variants for O67323

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O67323

No associated diseases with O67323

4 regional properties for O67323

Type Name Position InterPro Accession
domain DHHA1 domain 728 - 865 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 648 - 691 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 7 - 551 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 3 - 704 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

6 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
amino acid binding Binding to an amino acid, organic acids containing one or more amino substituents.
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.
tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSLSAHEIRE LFLSFFEKKG HTRVKSAPLV PENDPTLLFV NAGMVPFKNV FLGLEKRPYK
70 80 90 100 110 120
RATSCQKCLR VSGKHNDLEQ VGYTSRHHTF FEMLGNFSFG DYFKKEAIEY AWEFVTEVLK
130 140 150 160 170 180
LPKEKLYVSV YKDDEEAYRI WNEHIGIPSE RIWRLGEEDN FWQMGDVGPC GPSSEIYVDR
190 200 210 220 230 240
GEEYEGDERY LEIWNLVFMQ YNRDENGVLT PLPHPNIDTG MGLERIASVL QGKNSNFEID
250 260 270 280 290 300
IIFPLIQFGE EVSGKKYGEK FETDVALRVI ADHLRAITFA ISDGVIPSNE GRGYVIRRIL
310 320 330 340 350 360
RRAMRFGYKL GIENPFLYKG VDLVVDIMKE PYPELELSRE FVKGIVKGEE KRFIKTLKAG
370 380 390 400 410 420
MEYIQEVIQK ALEEGRKTLS GKEVFTAYDT YGFPVDLIDE IAREKGLGID LEGFQCELEE
430 440 450 460 470 480
QRERARKHFK VEAKKVKPVY SHLKELGKTS AFVGYEHMEW ESQVVGLVKG EGLVSELKEG
490 500 510 520 530 540
EEGEVVLKET PFYPEGGGQI GDAGIIESDK ALFKVEDTQK PTEGIIVHIG KVLKGTLKVG
550 560 570 580 590 600
DTVHARVDKE RRWDIMRNHT ATHLLHAALR NVLGEHVRQA GSLVADKYLR FDFTHFSALT
610 620 630 640 650 660
EEELKRVEEL VNEKIRENLP VNVMEMAYDE ALKTGAIAIF EEKYGERVRV ISCGEFSKEL
670 680 690 700 710 720
CGGTHVSATG DIGYFKIISE SSVGAGVRRI VAQTGRWSVE TAFKEHQTLK KASSALGVGE
730 740 750 760 770 780
EEVIQKIEEL KEEIKDRERE IQRLKQELLK LQIREVVKEE NVGDFTLHYG VFEEVEPEEL
790 800 810 820 830 840
RNLADMLRQR TKKDVVFIAS RKGDKINFVI GVSKEISDKV NAKEVIREVG KVLKGGGGGR
850 860
ADLAQGGGKA PDKFPEAVKL LKEILSG