O67266

PR
Gene name
flhF (aq_1214)
Protein name
Flagellar biosynthesis protein FlhF
Names
Flagella-associated GTP-binding protein
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_1214
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

25-118 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O67266

Entry ID Method Resolution Chain Position Source
AF-O67266-F1 Predicted AlphaFoldDB

No variants for O67266

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O67266

No associated diseases with O67266

3 regional properties for O67266

Type Name Position InterPro Accession
domain Signal recognition particle, SRP54 subunit, GTPase domain 172 - 361 IPR000897
domain AAA+ ATPase domain 171 - 337 IPR003593
domain Flagellar biosynthesis protein FlhF, GTPase domain 173 - 359 IPR047040

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
signal recognition particle binding Binding to a signal recognition particle.

3 GO annotations of biological process

Name Definition
bacterial-type flagellum organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility.
protein targeting The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKIEKIEVNS LQEAIEIVER RFGENAVILS SRVIRKNRFG FLPIFRKKIL EVTVGIREEE
70 80 90 100 110 120
DFRKEFERER ELIKEIENLK KIVNELINNG EVKGEKIVEK GSDTYAPRVK RYLEKLVIKN
130 140 150 160 170 180
ISKNIAEKII QDACGYDIDN KIYDFKDEPY TSLRESIEKN IKLNEEFIQN PPKVVALVGP
190 200 210 220 230 240
TGVGKTTTLA KLAHLFKKNK KKVGIISLDC FRVGAFEQLK AFAEVLEVPF KLADSPRAFN
250 260 270 280 290 300
IQLLEMDDRD VILVDTAGRS HYDVIRLKEL ETYFKVSDIS VYLTLAANLS ELVMYEAIMQ
310 320 330 340 350 360
FGMFSISGLI FTKLDETPYP GSMVNVAYRT QYPVVCFTMG QSIPEDIVVA NYDYLVRLIL
370
EDEDEVRPAT QLA