O67258

PR
Gene name
lysS (aq_1202)
Protein name
Lysine--tRNA ligase
Names
Lysyl-tRNA synthetase, LysRS
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_1202
EC number
6.1.1.6: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

28-170 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O67258

Entry ID Method Resolution Chain Position Source
AF-O67258-F1 Predicted AlphaFoldDB

No variants for O67258

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O67258

No associated diseases with O67258

4 regional properties for O67258

Type Name Position InterPro Accession
binding_site Catalase haem-binding site 333 - 341 IPR002226
domain Catalase immune-responsive domain 415 - 475 IPR010582
domain Catalase core domain 7 - 391 IPR011614
active_site Catalase active site 43 - 59 IPR024708

Functions

Description
EC Number 6.1.1.6 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
lysine-tRNA ligase activity Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
magnesium ion binding Binding to a magnesium (Mg) ion.
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLSLLSSEIF FSAIQYNLSL MEEVRLKKLQ ELREKGINPY PYRFEVTDFI GNIRKQYEEE
70 80 90 100 110 120
PPENYKVRVK GVAKRVSRTE NGYMVRLADE KGIEILVFTK EEGLKPKESY TFEGILKRVE
130 140 150 160 170 180
GKLSLVEAVL TEEEGEEVYK IKEQFDYDPN FRPVSLAGRL VSMRSMGKAI FGHIQDLTGK
190 200 210 220 230 240
IQIYLKKDVI GEEKLKFFND YIDVGDIVGV RGKLFRTNTG ELTVEVEEYQ LLAKSLHPLP
250 260 270 280 290 300
EKWHGLKDVE VRYRQRYLDL IANPEARRIF MLRTKLITEM RKFFEMHGFI EVETPILQPI
310 320 330 340 350 360
ASGANARPFV TYHNFLETEL YLRIAPELYL KRLIVGGFPR VYEIGKNFRN ESVDRTHNPE
370 380 390 400 410 420
FTMVEFYAAY WDYHDLIKFT EDMFVYLLEK TLGTLKVKYG EWELDFSPPF KKVRYFDLLK
430 440 450 460 470 480
EKTGKDKDFF LKDLEGLRKL AKELEIPDVE RMTHAKLLDK VFEKVAEEDL IQPTFVIDFP
490 500 510 520 530 540
KILSPLAKTH REDPDLVERF ELIIARYEVA NAYTELNDPF DQKERFLEQL KEKQMGDEEA
550 560 570 580 590
MDMDEDFIRA LEYGMPPTAG EGIGIDRLVM ILANTDSIRE VILFPQLKPE KKKKEAP