O67163

PR
Gene name
cysS (aq_1068)
Protein name
Cysteine--tRNA ligase
Names
Cysteinyl-tRNA synthetase, CysRS
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_1068
EC number
6.1.1.16: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

293-379 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O67163

Entry ID Method Resolution Chain Position Source
AF-O67163-F1 Predicted AlphaFoldDB

No variants for O67163

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O67163

No associated diseases with O67163

2 regional properties for O67163

Type Name Position InterPro Accession
domain Cysteinyl-tRNA synthetase, class Ia, DALR 355 - 428 IPR015273
domain tRNA synthetases class I, catalytic domain 4 - 312 IPR032678

Functions

Description
EC Number 6.1.1.16 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cysteine-tRNA ligase activity Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSLRIYNTLS GKVEEFVPIN PPKVLIYTCG VTVYDDSHVG HGRSLIVFDV FRRFLEHLGY
70 80 90 100 110 120
QVKFVRNFTD VDDKIINRAK QECTDFMTIA DRYIARYYVD MENIRVRPAD VEPRVTEHIP
130 140 150 160 170 180
EIIEVIQKLV EKGYAYVVEG DVYFSVKKFK DYGKLSKRDI EELIAGARVE PSEKKRDPLD
190 200 210 220 230 240
FALWKASKAG EPAWDSPWGK GRPGWHTECV AMVFKHLGET IDIHGGGLDL VFPHHENEIA
250 260 270 280 290 300
QAEAITGKPF ARYWMHNGLV TVGGQKMSKS LGNYVTLREV YTKYHPDVLR LLVLFTHYRS
310 320 330 340 350 360
PLDFSWEKME ETLKAYERLK NAIEDLELLK KLQVVESKEG GTHPLYEQVK EFEENFYASL
370 380 390 400 410 420
SDDFNTPEAL SHVYKLVGEL NKVKNKAYSE GKITDRELSA YEFASKSLLN TMKKIFGLLE
430 440 450 460 470 480
DLYPECKVER VVERELEAGQ VFDEKLIQIL IEARNIARKE KVFKVADYIR DKLKELGIVL
490
EDTPAGTKWK KREGA