O67012
Gene name |
spoT (aq_844) |
Protein name |
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase |
Names |
Penta-phosphate guanosine-3'-pyrophosphohydrolase, (ppGpp)ase |
Species |
Aquifex aeolicus (strain VF5) |
KEGG Pathway |
aae:aq_844 |
EC number |
3.1.7.2: Diphosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O67012
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O67012-F1 | Predicted | AlphaFoldDB |
No variants for O67012
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O67012 | |||||
No associated diseases with O67012
7 regional properties for O67012
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ACT domain | 619 - 696 | IPR002912 |
| domain | HD/PDEase domain | 45 - 167 | IPR003607 |
| domain | TGS | 383 - 446 | IPR004095 |
| domain | HD domain | 49 - 145 | IPR006674 |
| domain | RelA/SpoT | 216 - 347 | IPR007685 |
| domain | RelA/SpoT, TGS domain | 388 - 446 | IPR033655 |
| domain | RelA/SpoT, AH and RIS domains | 459 - 549 | IPR045600 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.7.2 | Diphosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity | Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| guanosine tetraphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSKLGEVSLE | EDLEKLLSHY | PQHAEEIQRA | YEFAKEKHGE | QKRKTGEPYI | IHPLNVALKL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AELGMDHETI | IAALLHDTLE | DTDTTYEEIK | ERFGERVAKL | VEGVTKIGKI | KYKSEQAENY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RKLILATAED | PRVILLKLSD | RLDNVKTLWV | FREEKRKKIA | KETMEIYAPL | AHRLGVWSIK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NELEDWAFKY | LYPEEYEKVR | NFVKESRKNL | EEYLRKYVIP | KVRKELEKYG | IEAEIKYRSK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HYYSIWEKTR | RKGIRLEDVH | DILGVRIIVN | TVPECYTVLG | IIHSLFRPVP | GKFKDYISLP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KPNLYQSLHT | TVIADKGKLV | EFQIRTWEMH | ERAEKGIASH | WAYKEGKNPS | DAGVYSWLRE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LVESIQGSTN | PSEVLENLKS | NLFFEEVFVF | TPKGDLVVLP | KGSTPVDLAY | KIHTEVGNHC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AGAKSNGRIV | PLNYELKSGD | VVEIITNPNK | SPSYEWLSFV | KTSRARNKIK | QFLKKQERER |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YLSEGKRILE | RIREKLGLSH | EDLINKIRER | VRFDTEEELL | LALGKRKISS | ANLIKLIFPK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KKEEKEERRG | SSTVFLEDLS | NIKHEVAKCC | KPIPGDEILG | VITRTKGLVL | HEKSCSNLKN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VLRLNPEKVK | EVQLQASGYF | QTDIRVVASD | RIGLLSDITK | VISESGSNIV | SSMTNTREGK |
| 670 | 680 | 690 | |||
| AVMDFTVEVK | NKEHLEKIMK | KIKSVEGVKI | CKRLYH |