O67010
Gene name |
trm1 |
Protein name |
tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase |
Names |
|
Species |
Aquifex aeolicus (strain VF5) |
KEGG Pathway |
aae:aq_841 |
EC number |
2.1.1.215: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for O67010
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3AXS | X-ray | 216 A | A | 1-392 | PDB |
| 3AXT | X-ray | 249 A | A | 1-392 | PDB |
| AF-O67010-F1 | Predicted | AlphaFoldDB |
No variants for O67010
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O67010 | |||||
No associated diseases with O67010
No regional properties for O67010
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O67010 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.215 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| tRNA (guanine-N2-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine. |
| tRNA binding | Binding to a transfer RNA. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA N2-guanine methylation | The process whereby a guanine in a tRNA is methylated at the N2 position of guanine. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEIVQEGIAK | IIVPEIPKTV | SSDMPVFYNP | RMRVNRDLAV | LGLEYLCKKL | GRPVKVADPL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SASGIRAIRF | LLETSCVEKA | YANDISSKAI | EIMKENFKLN | NIPEDRYEIH | GMEANFFLRK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EWGFGFDYVD | LDPFGTPVPF | IESVALSMKR | GGILSLTATD | TAPLSGTYPK | TCMRRYMARP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LRNEFKHEVG | IRILIKKVIE | LAAQYDIAMI | PIFAYSHLHY | FKLFFVKERG | VEKVDKLIEQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FGYIQYCFNC | MNREVVTDLY | KFKEKCPHCG | SKFHIGGPLW | IGKLWDEEFT | NFLYEEAQKR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EEIEKETKRI | LKLIKEESQL | QTVGFYVLSK | LAEKVKLPAQ | PPIRIAVKFF | NGVRTHFVGD |
| 370 | 380 | 390 | |||
| GFRTNLSFEE | VMKKMEELKE | KQKEFLEKKK | QG |