O66880

PR
Gene name
ligA
Protein name
DNA ligase
Names
Polydeoxyribonucleotide synthase [NAD(+)]
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_633
EC number
6.5.1.2: Forming phosphoric ester bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O66880

Entry ID Method Resolution Chain Position Source
AF-O66880-F1 Predicted AlphaFoldDB

No variants for O66880

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O66880

No associated diseases with O66880

11 regional properties for O66880

Type Name Position InterPro Accession
domain BRCT domain 619 - 699 IPR001357
domain Helix-hairpin-helix DNA-binding motif, class 1 475 - 494 IPR003583-1
domain Helix-hairpin-helix DNA-binding motif, class 1 509 - 528 IPR003583-2
domain Helix-hairpin-helix DNA-binding motif, class 1 573 - 592 IPR003583-3
domain Zinc-finger, NAD-dependent DNA ligase C4-type 438 - 463 IPR004149
domain NAD-dependent DNA ligase, OB-fold 352 - 428 IPR004150
domain NAD-dependent DNA ligase, adenylation 31 - 347 IPR013839
domain NAD-dependent DNA ligase, N-terminal 31 - 477 IPR013840
active_site NAD-dependent DNA ligase, active site 142 - 171 IPR018239
conserved_site NAD-dependent DNA ligase, conserved site 361 - 376 IPR033136
domain DisA/LigA, helix-hairpin-helix motif 539 - 601 IPR041663

Functions

Description
EC Number 6.5.1.2 Forming phosphoric ester bonds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA ligase (NAD+) activity Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
base-excision repair, DNA ligation The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFTPEREKEL QEKTRELLRK IKDVKVLSFE EAKKLAEDLR EVIRYHDYKY YVEANPVIPD
70 80 90 100 110 120
YDYDRLFRAL KEIEKKYPEL ITPDSPTQRV ASEISGEFPT VKHYTPMLSL DNAYSEDELR
130 140 150 160 170 180
EFDRRVRQIT GLEVVEYAVE PKLDGAGIAL VYENDLFVRG ATRGDGEYGE DITNNLKTIK
190 200 210 220 230 240
TIPLKAEFSR FGIKLAEIRG EVVIRKDEFQ KLNKERMEEG LPPFANPRNA AAGSIRQKDP
250 260 270 280 290 300
KEVAKRNLEA IVYHLSYVEP PETEPPTHYE SLKMLHTLGF KTLFKDTKVC KGIDEVIEYC
310 320 330 340 350 360
KEWEKKRDSY PYEIDGMVVK VNDRRLWKVL GYTSHHPRWA IAYKFKPRRA VTKLVDVVFQ
370 380 390 400 410 420
VGRTGTITPV GKLEPVELGG VTVSSVSLFN EDFIREKDIR IGDWVVVERA GDVIPYVVEV
430 440 450 460 470 480
LKEKRTGEEK PVEFPKYCPS CGSELVKLPE EVAIRCINIS CPAQSVLRIK HWASRDAMDI
490 500 510 520 530 540
RGLGDATIKL LFNRGLAKDV GDLYYLKLTD ILKLPGFGEK SAMNLLKAIE ESKNRPLDRV
550 560 570 580 590 600
LYGLGIRYVG QTTAKKIAEI INSVWDLKDI PLEKLMRLEG IGYKVARSIK EFFNIPQNLE
610 620 630 640 650 660
VLKKLEKAGV NLAKKVKEKV ADVLKGKTFV FTGTLDCCSR EKAGEIVEML GGKFSNSVTS
670 680 690 700 710
KTDYLVVGKD PGATKLSKAK KYGVKTITEE EFVNMIKDYV DLEKIKKEDK KEKPKIGRLF