O66839

PR
Gene name
aq_568
Protein name
Probable 6-oxopurine nucleoside phosphorylase
Names
Purine nucleoside phosphorylase, PNP
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_568
EC number
2.4.2.1: Pentosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-62 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O66839

Entry ID Method Resolution Chain Position Source
AF-O66839-F1 Predicted AlphaFoldDB

No variants for O66839

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O66839

No associated diseases with O66839

2 regional properties for O66839

Type Name Position InterPro Accession
domain Nucleoside phosphorylase domain 2 - 258 IPR000845
conserved_site Purine phosphorylase, family 2, conserved site 48 - 88 IPR018099

Functions

Description
EC Number 2.4.2.1 Pentosyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

1 GO annotations of molecular function

Name Definition
S-methyl-5-thioadenosine phosphorylase activity Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate.

2 GO annotations of biological process

Name Definition
L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.
purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLGIIGGSGL YNLPGIKVKE EVQVKTPFGE PSSPVVIAEV EGKKVAFLAR HGRGHEYPPH
70 80 90 100 110 120
LVPYRANLWA LREVGVKRVL GISAVGGINE LLMPGDFVVI HDYLDFTKTR RSTYYEGKFS
130 140 150 160 170 180
VKVEGEDKVA KLLREGKVVH VDMSEAYCPE MRKVLIQILK EKNFRFHPKG VYACTEGPRF
190 200 210 220 230 240
ETPSEIKMLK LLGADVVGMT GYPEVALARE LTMCYASLCV VANPAAGIAG YRLTSNEVIQ
250 260 270
LMKRKEEEIK EVVLKFIKEL PEIRSCDCEK SLEGAEV