O66680

PR
Gene name
leuS (aq_351)
Protein name
Leucine--tRNA ligase subunit alpha
Names
Leucyl-tRNA synthetase subunit alpha, LeuRS
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_351
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

383-452 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for O66680

Entry ID Method Resolution Chain Position Source
3O0A X-ray 177 A A/B 225-443 PDB
3PZ0 X-ray 240 A A/B/C/D 228-439 PDB
3PZ5 X-ray 250 A A/B 228-439 PDB
AF-O66680-F1 Predicted AlphaFoldDB

No variants for O66680

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O66680

No associated diseases with O66680

4 regional properties for O66680

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 41 - 52 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 13 - 170 IPR002300-1
domain Aminoacyl-tRNA synthetase, class Ia 443 - 599 IPR002300-2
domain Leucyl-tRNA synthetase, editing domain 221 - 429 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMKEFNPREI EKKWQKRWEE AGVFKAQEGK PNKFYVLEMF PYPSGRIHMG HVRNYTIGDA
70 80 90 100 110 120
IARYLKMRGK NILHPMGWDA FGLPAENAAI KHGIHPAKWT YENIDYMKKQ LKILGFSYDW
130 140 150 160 170 180
DREIATCDPE YYKWNQWIFL KMLERGIAYR KTAKVNWCPH DQTVLANEQV IEGKCWRCGT
190 200 210 220 230 240
PIVQKEVPSW FLRITAYADR LLEDLKKLEG KWPERVIAQQ RNWIGRSEGA LIRFYVEIEE
250 260 270 280 290 300
PEKFLNCVPE ELKETLLKEK RIYIDVFTTR PDTVFGATFV VLAPEHPLVP VLACIGERLG
310 320 330 340 350 360
NACYSDVENF VEKMKKMSTR ERTMEEDKEG VFLGVYATNP ANGEKIPVWS ANYVLYEYGT
370 380 390 400 410 420
GAIMCVPAHD QRDWEFAKKY DLPIKVVVKP EGAWDFEKGA YEGKGTLVNS DGFDGLDSET
430 440 450 460 470 480
AKRKITEWLQ DRGLGEKKVS YRLRDWNISR QRYWGTPIPV VYCEKCGMVP VPEDQLPVKL
490 500 510 520 530 540
PLDVKFTGQG NPLETSEEFV NTTCPKCGGK ARRETDTMDT FFDSSWYFLR FCDPKNDREP
550 560 570 580 590 600
FSREKVDYWM PVDVYIGGIE HAVLHLLYAR FFQKFLKDLG LVRDDEPFEK LITQGMVLKK
610 620 630
WVSVKKLLDY LGLSEEDEVE ELKKRLEELG ARRA