O66659

PR
Gene name
dnaA (aq_322)
Protein name
Chromosomal replication initiator protein DnaA
Names
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_322
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

33-106 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for O66659

Entry ID Method Resolution Chain Position Source
1L8Q X-ray 270 A A 76-399 PDB
2HCB X-ray 351 A A/B/C/D 77-399 PDB
3R8F X-ray 337 A A/B/C/D 76-399 PDB
AF-O66659-F1 Predicted AlphaFoldDB

No variants for O66659

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O66659

No associated diseases with O66659

4 regional properties for O66659

Type Name Position InterPro Accession
domain AAA+ ATPase domain 111 - 251 IPR003593
domain Chromosomal replication initiator, DnaA C-terminal 304 - 393 IPR013159
domain Chromosomal replication initiator protein DnaA 79 - 287 IPR013317
conserved_site Chromosomal replication control, initiator DnaA, conserved site 354 - 373 IPR018312

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA replication origin binding Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
identical protein binding Binding to an identical protein or proteins.

3 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
DNA replication initiation The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
regulation of DNA replication Any process that modulates the frequency, rate or extent of DNA replication.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MELNALIKKI ESVDSYAREF LKKFEIKQEK GKFLFIAPGE DYREWLETIV NTFLEEEVRK
70 80 90 100 110 120
LIEVKEKEEK KKVEIKDFLN PKYTLENFIV GEGNRLAYEV VKEALENLGS LYNPIFIYGS
130 140 150 160 170 180
VGTGKTHLLQ AAGNEAKKRG YRVIYSSADD FAQAMVEHLK KGTINEFRNM YKSVDLLLLD
190 200 210 220 230 240
DVQFLSGKER TQIEFFHIFN TLYLLEKQII LASDRHPQKL DGVSDRLVSR FEGGILVEIE
250 260 270 280 290 300
LDNKTRFKII KEKLKEFNLE LRKEVIDYLL ENTKNVREIE GKIKLIKLKG FEGLERKERK
310 320 330 340 350 360
ERDKLMQIVE FVANYYAVKV EDILSDKRNK RTSEARKIAM YLCRKVCSAS LIEIARAFKR
370 380 390
KDHTTVIHAI RSVEEEKKKD RKFKHLVGFL EKQAFDKIC