O66630

PR
Gene name
dapL
Protein name
LL-diaminopimelate aminotransferase
Names
DAP-AT, DAP-aminotransferase, LL-DAP-aminotransferase
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_273
EC number
2.6.1.83: Transaminases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

8-86 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O66630

Entry ID Method Resolution Chain Position Source
AF-O66630-F1 Predicted AlphaFoldDB

No variants for O66630

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O66630

No associated diseases with O66630

2 regional properties for O66630

Type Name Position InterPro Accession
binding_site Aminotransferases, class-I, pyridoxal-phosphate-binding site 236 - 249 IPR004838
domain Aminotransferase, class I/classII 32 - 382 IPR004839

Functions

Description
EC Number 2.6.1.83 Transaminases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
L,L-diaminopimelate aminotransferase activity Catalysis of the reaction: 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H(2)O + H(+).
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

1 GO annotations of biological process

Name Definition
lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in two enzymatic steps.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFEFSDRLKV LPPYLFAELD RKKQEKIEQG VDVIDLGVGD PDMPTPKPIV EAAKKALENP
70 80 90 100 110 120
ENHKYPSYVG KYEFRKAVAD WYKRRFDVDL DPNTEVITLI GSKEGIAHFP LAFVNPGDIV
130 140 150 160 170 180
LCPDPAYPVY RIGAIFAGGT PYTVPLKEEN NFLPDLDSIP EDVAKKAKII WINYPNNPTS
190 200 210 220 230 240
APPTLEFYKK LVDWAKEYNV IIASDNAYSE IYTGQEKPPS ILQVPGAKDV AIEFHSLSKT
250 260 270 280 290 300
YNMTGWRIGM AVGNKELVAG LGKVKTNVDS GQFGAVQDAG IVALNLPEEE VEKIRDVYRE
310 320 330 340 350 360
RKKIMTEALE KIGLEIYRSD YTFYLWIKVP EGYTSAEFVG RLIDEAGIVC TPGNGFGEYG
370 380
EGYFRISLTV PTERLLEAAE RIKNLKL