O66612

PR
Gene name
ogg
Protein name
8-oxoguanine DNA glycosylase/AP lyase
Names
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_251
EC number
4.2.99.18: Other carbon-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

81-156 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O66612

Entry ID Method Resolution Chain Position Source
AF-O66612-F1 Predicted AlphaFoldDB

No variants for O66612

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O66612

No associated diseases with O66612

1 regional properties for O66612

Type Name Position InterPro Accession
domain HhH-GPD domain 48 - 221 IPR003265

Functions

Description
EC Number 4.2.99.18 Other carbon-oxygen lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
class I DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.
hydrolase activity, hydrolyzing N-glycosyl compounds Catalysis of the hydrolysis of any N-glycosyl bond.

1 GO annotations of biological process

Name Definition
base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDAIQEVKRI IPEVQKYVNQ RMEEFERLGR EGWTHFDFRP FLDIDYDAGL FSELSFCILT
70 80 90 100 110 120
ANSSATLGIK IQAHLGEEGF LNKTKEELEE VFRKFGHRYA GQRAERIVEA REKFPKVKSL
130 140 150 160 170 180
IEKEKNSKVI RELLADPKSP YKIKGFGYKE ASHFLRNIGF KDLAIIDRHI SRFLMEKGLL
190 200 210 220
RQVKSITPKV YLEAEKALES LAKELGLSLG ELDLYIFYIK TKKVLK