O66610

PR
Gene name
gatA (aq_247)
Protein name
Glutamyl-tRNA(Gln) amidotransferase subunit A
Names
Glu-ADT subunit A
Species
Aquifex aeolicus (strain VF5)
KEGG Pathway
aae:aq_247
EC number
6.3.5.7: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

117-192 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for O66610

Entry ID Method Resolution Chain Position Source
3H0L X-ray 230 A A/D/G/J/M/P/S/V 1-478 PDB
3H0M X-ray 280 A A/D/G/J/M/P/S/V 1-478 PDB
3H0R X-ray 300 A A/D/G/J/M/P/S/V 1-478 PDB
AF-O66610-F1 Predicted AlphaFoldDB

No variants for O66610

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O66610

No associated diseases with O66610

2 regional properties for O66610

Type Name Position InterPro Accession
conserved_site Amidase, conserved site 145 - 176 IPR020556
domain Amidase signature domain 23 - 459 IPR023631

Functions

Description
EC Number 6.3.5.7 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
glutamyl-tRNA(Gln) amidotransferase complex A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP.

1 GO annotations of biological process

Name Definition
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLWKKSLSEL RELLKRGEVS PKEVVESFYD RYNQTEEKVK AYITPLYGKA LKQAESLKER
70 80 90 100 110 120
ELPLFGIPIA VKDNILVEGE KTTCASKILE NFVAPYDATV IERLKKAGAL IVGKTNLDEF
130 140 150 160 170 180
AMGSSTEYSA FFPTKNPWDL ERVPGGSSGG SAASVAVLSA PVSLGSDTGG SIRQPASFCG
190 200 210 220 230 240
VIGIKPTYGR VSRYGLVAFA SSLDQIGVFG RRTEDVALVL EVISGWDEKD STSAKVPVPE
250 260 270 280 290 300
WSEEVKKEVK GLKIGLPKEF FEYELQPQVK EAFENFIKEL EKEGFEIKEV SLPHVKYSIP
310 320 330 340 350 360
TYYIIAPSEA SSNLARYDGV RYGYRAKEYK DIFEMYARTR DEGFGPEVKR RIMLGTFALS
370 380 390 400 410 420
AGYYDAYYLK AQKVRRLITN DFLKAFEEVD VIASPTTPTL PFKFGERLEN PIEMYLSDIL
430 440 450 460 470
TVPANLAGLP AISIPIAWKD GLPVGGQLIG KHWDETTLLQ ISYLWEQKFK HYEKIPLT