O66381

PR
Gene name
sigA
Protein name
RNA polymerase sigma factor SigA
Names
Sigma-43, Sigma-A
Species
Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) (Bacillus halodurans)
KEGG Pathway
bha:BH1376
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

51-121 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O66381

Entry ID Method Resolution Chain Position Source
AF-O66381-F1 Predicted AlphaFoldDB

No variants for O66381

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O66381

No associated diseases with O66381

11 regional properties for O66381

Type Name Position InterPro Accession
domain RNA polymerase sigma-70 163 - 176 IPR000943-1
domain RNA polymerase sigma-70 187 - 195 IPR000943-2
domain RNA polymerase sigma-70 311 - 323 IPR000943-3
domain RNA polymerase sigma-70 332 - 358 IPR000943-4
domain RNA polymerase sigma factor 70, region 1.1 16 - 85 IPR007127
domain RNA polymerase sigma-70 region 3 218 - 294 IPR007624
domain RNA polymerase sigma-70 region 2 139 - 208 IPR007627
domain RNA polymerase sigma-70 region 4 307 - 360 IPR007630
domain RNA polymerase sigma-70 region 1.2 101 - 134 IPR009042
domain RNA polymerase sigma factor RpoD, C-terminal 135 - 371 IPR012760
domain RNA polymerase sigma-70 like domain 135 - 360 IPR014284

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
sigma factor activity Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.

1 GO annotations of biological process

Name Definition
DNA-templated transcription initiation The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAEKPLRPLA EGELSIDQVK EQLVELGKKR GVLTYAEITE KLAPYDQDSD QMDEFFEYLG
70 80 90 100 110 120
EQGVEILNDN EEVPSLQQVE KEEEEFDLND LSVPPGVKIN DPVRMYLKEI GRVPLLTAEE
130 140 150 160 170 180
EIELATRIEQ GDEEAKRRLA EANLRLVVSI AKRYVGRGML FLDLIQEGNM GLIKAVEKFD
190 200 210 220 230 240
YNKGFKFSTY ATWWIRQAIT RAIADQARTI RIPVHMVETI NKLIRVQRQL LQDLGREPSP
250 260 270 280 290 300
EEVAEEMDLT PEKVREILKI AQEPVSLETP IGEEDDSHLG DFIEDQDALA PSDAAAYELL
310 320 330 340 350 360
KEQLEDVLDT LTDREENVLR LRFGLDDGRT RTLEEVGKVF GVTRERIRQI EAKALRKLRH
370
PSRSKRLKDF LE