O65201

PR
Gene name
ACX2
Protein name
Acyl-coenzyme A oxidase 2, peroxisomal
Names
AOX 2, Long-chain acyl-CoA oxidase, AtCX2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G65110
EC number
1.3.3.6: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-85 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O65201

Entry ID Method Resolution Chain Position Source
AF-O65201-F1 Predicted AlphaFoldDB

19 variants for O65201

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH07481297 2 E>K No 1000Genomes
ENSVATH03476760 9 P>L No 1000Genomes
ENSVATH07481296 18 L>I No 1000Genomes
tmp_5_26012421_G_A 21 A>V No 1000Genomes
ENSVATH12935623 38 S>L No 1000Genomes
tmp_5_26012233_A_G 84 S>P No 1000Genomes
ENSVATH07481294 108 I>K No 1000Genomes
tmp_5_26012126_A_T 119 F>L No 1000Genomes
tmp_5_26012127_A_T 119 F>Y No 1000Genomes
ENSVATH07481289 167 R>I No 1000Genomes
ENSVATH12935619 204 D>H No 1000Genomes
ENSVATH03476758 253 M>L No 1000Genomes
tmp_5_26011200_T_C 352 K>R No 1000Genomes
ENSVATH00752232 403 V>L No 1000Genomes
ENSVATH07481285 437 S>C No 1000Genomes
ENSVATH12935616 494 K>N No 1000Genomes
ENSVATH00752230 592 A>T No 1000Genomes
ENSVATH07481274 658 A>V No 1000Genomes
tmp_5_26009895_C_T 669 D>N No 1000Genomes

No associated diseases with O65201

3 regional properties for O65201

Type Name Position InterPro Accession
domain Acyl-CoA oxidase, C-terminal 535 - 679 IPR002655
domain Acyl-CoA oxidase/dehydrogenase, middle domain 182 - 298 IPR006091
domain Acyl-CoA dehydrogenase/oxidase C-terminal 332 - 489 IPR009075

Functions

Description
EC Number 1.3.3.6 With oxygen as acceptor
Subcellular Localization
  • Peroxisome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

4 GO annotations of molecular function

Name Definition
acyl-CoA oxidase activity Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide.
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
fatty acid binding Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.

4 GO annotations of biological process

Name Definition
fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
fatty acid beta-oxidation using acyl-CoA oxidase A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
lipid homeostasis Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
long-chain fatty acid metabolic process The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9EPL9 Acox3 Peroxisomal acyl-coenzyme A oxidase 3 Mus musculus (Mouse) PR
10 20 30 40 50 60
MESRREKNPM TEEESDGLIA ARRIQRLSLH LSPSLTPSPS LPLVQTETCS ARSKKLDVNG
70 80 90 100 110 120
EALSLYMRGK HIDIQEKIFD FFNSRPDLQT PIEISKDDHR ELCMNQLIGL VREAGVRPFR
130 140 150 160 170 180
YVADDPEKYF AIMEAVGSVD MSLGIKMGVQ YSLWGGSVIN LGTKKHRDKY FDGIDNLDYT
190 200 210 220 230 240
GCFAMTELHH GSNVQGLQTT ATFDPLKDEF VIDTPNDGAI KWWIGNAAVH GKFATVFARL
250 260 270 280 290 300
ILPTHDSKGV SDMGVHAFIV PIRDMKTHQT LPGVEIQDCG HKVGLNGVDN GALRFRSVRI
310 320 330 340 350 360
PRDNLLNRFG DVSRDGTYTS SLPTINKRFG ATLGELVGGR VGLAYASVGV LKISATIAIR
370 380 390 400 410 420
YSLLRQQFGP PKQPEVSILD YQSQQHKLMP MLASTYAYHF ATVYLVEKYS EMKKTHDEQL
430 440 450 460 470 480
VADVHALSAG LKSYVTSYTA KALSVCREAC GGHGYAAVNR FGSLRNDHDI FQTFEGDNTV
490 500 510 520 530 540
LLQQVAADLL KRYKEKFQGG TLTVTWSYLR ESMNTYLSQP NPVTARWEGE DHLRDPKFQL
550 560 570 580 590 600
DAFRYRTSRL LQNVAARLQK HSKTLGGFGA WNRCLNHLLT LAESHIETVI LAKFIEAVKN
610 620 630 640 650 660
CPDPSAKAAL KLACDLYALD RIWKDIGTYR NVDYVAPNKA KAIHKLTEYL SFQVRNVAKE
670 680 690
LVDAFELPDH VTRAPIAMQS DAYSQYTQVV GF