O64903

PR
Gene name
NDPK2 (At5g63310, MDC12.28)
Protein name
Nucleoside diphosphate kinase II, chloroplastic
Names
NDK II, NDP kinase II, NDPK II, NDPK Ia
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G63310
EC number
2.7.4.6: Phosphotransferases with a phosphate group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-103 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for O64903

Entry ID Method Resolution Chain Position Source
1S57 X-ray 180 A A/B/C/D/E/F 79-231 PDB
1S59 X-ray 260 A A/B/C/D/E/F 79-231 PDB
AF-O64903-F1 Predicted AlphaFoldDB

22 variants for O64903

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH03468937 14 C>Y No 1000Genomes
ENSVATH03468936 18 P>T No 1000Genomes
tmp_5_25373783_G_T 19 P>Q No 1000Genomes
ENSVATH07472224 29 H>Y No 1000Genomes
ENSVATH07472223 33 A>S No 1000Genomes
tmp_5_25373741_G_A 33 A>V No 1000Genomes
ENSVATH00749195 36 N>Y No 1000Genomes
ENSVATH03468935 40 A>E No 1000Genomes
ENSVATH07472220 59 R>S No 1000Genomes
tmp_5_25373637_C_T 68 E>K No 1000Genomes
tmp_5_25373366_C_G 98 G>A No 1000Genomes
tmp_5_25373210_C_T 102 E>K No 1000Genomes
tmp_5_25373206_A_G 103 I>T No 1000Genomes
tmp_5_25373152_T_C 121 Q>R No 1000Genomes
ENSVATH14646645 161 G>D No 1000Genomes
tmp_5_25372710_C_T 164 A>T No 1000Genomes
tmp_5_25372695_G_C 169 L>V No 1000Genomes
ENSVATH12916666 176 L>H No 1000Genomes
ENSVATH12916665 207 R>H No 1000Genomes
ENSVATH03468925 209 I>N No 1000Genomes
ENSVATH07472203 223 S>L No 1000Genomes
tmp_5_25372141_G_A 226 A>V No 1000Genomes

No associated diseases with O64903

2 regional properties for O64903

Type Name Position InterPro Accession
active_site Nucleoside diphosphate kinase, active site 194 - 202 IPR023005
domain Nucleoside diphosphate kinase-like domain 83 - 220 IPR034907

Functions

Description
EC Number 2.7.4.6 Phosphotransferases with a phosphate group as acceptor
Subcellular Localization
  • Plastid, chloroplast
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
chloroplast envelope The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
chloroplast stroma The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
nucleoside diphosphate kinase activity Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

8 GO annotations of biological process

Name Definition
auxin-activated signaling pathway The series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription.
CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate.
GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate.
nucleoside diphosphate phosphorylation The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate.
red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm.
response to hydrogen peroxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
response to UV Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8N427 NME8 Thioredoxin domain-containing protein 3 Homo sapiens (Human) PR
10 20 30 40 50 60
MVGATVVSKW TPLCVASPPE RNSASLNPHC SPARVNFRTA LAAFRPQFRL FSRNSASRRR
70 80 90 100 110 120
LRASSSAESG IFLPHLVASM EDVEETYIMV KPDGIQRGLV GEIISRFEKK GFKLIGLKMF
130 140 150 160 170 180
QCPKELAEEH YKDLSAKSFF PNLIEYITSG PVVCMAWEGV GVVASARKLI GKTDPLQAEP
190 200 210 220 230
GTIRGDLAVQ TGRNIVHGSD SPENGKREIG LWFKEGELCK WDSALATWLR E