O64299
Gene name |
46 |
Protein name |
Exonuclease subunit 2 |
Names |
Protein Gp46 |
Species |
Escherichia phage RB69 (Bacteriophage RB69) |
KEGG Pathway |
vg:1494179 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for O64299
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|
No variants for O64299
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O64299 | |||||
No associated diseases with O64299
1 regional properties for O64299
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Rad50/SbcC-type AAA domain | 8 - 245 | IPR038729 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent DNA damage sensor activity | A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis. |
| exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKSFKLNRVR | YQNIMSVGGN | PIDIQLDKVQ | KTLITGKNGG | GKSTMLEAIT | FGLFGKPFRD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VKKGQIINST | NKKELLVELW | MEFDDKKYFI | KRGQKPNIFE | ISVDGVRLDE | SASSRDFQEE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FERSIGMSYA | SFKQIVVLGT | AGYTPFMALS | TPARRKLVED | LLEVGTLAEM | DKINKSQVRE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LNSQGQVLDA | KKDGVIQQIK | IYNENIERQK | KLSGDNVARL | QNMYDDLAKE | ARSLKAEIEE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ANERLLNIVL | DEDPTEAFNK | IGQEAFLIKS | KIDSYNKVIK | MYHDGGTCPT | CASQLHQGDP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IVSKITDKLH | ECNHSFEQLT | CHRDNLSVLV | DEYRANVKTK | QDLASDIRTK | KQAMIATIDK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AKKVKAAIEQ | ASAEFIDHAD | EIALLQKELD | KIIKTKSDIV | LEKYHRGIIT | DMLKDSGIKG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AIIKKYVPLF | NKQINHYLKI | MEADYVFSID | EEFNESIKSR | GREEFSYASF | SQGEKARIDI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ALLFTWRDIA | EKVSGVRINT | LIMDEVMDSA | TDSEGIKAIS | TILNSLTDAN | VFIISHRDHD |
| 550 | 560 | ||||
| PQAYGQHLQM | SKVGRFTVMT | VS |