O63908

PR
Gene name
MT-ND5 (MTND5, NADH5, ND5)
Protein name
NADH-ubiquinone oxidoreductase chain 5
Names
NADH dehydrogenase subunit 5
Species
Glis glis (Fat dormouse) (Myoxus glis)
KEGG Pathway
EC number
7.1.1.2: Hydron translocation or charge separation linked to oxidoreductase reactions
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

537-603 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O63908

Entry ID Method Resolution Chain Position Source
AF-O63908-F1 Predicted AlphaFoldDB

No variants for O63908

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O63908

No associated diseases with O63908

3 regional properties for O63908

Type Name Position InterPro Accession
domain NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal 68 - 118 IPR001516
domain NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit 134 - 418 IPR001750
domain NADH dehydrogenase subunit 5, C-terminal 422 - 602 IPR010934

Functions

Description
EC Number 7.1.1.2 Hydron translocation or charge separation linked to oxidoreductase reactions
Subcellular Localization
  • Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
respirasome The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

1 GO annotations of molecular function

Name Definition
NADH dehydrogenase (ubiquinone) activity Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).

1 GO annotations of biological process

Name Definition
ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNLFSSFTLM TFSILLYPIL LSFTDQYNNN LFPNHVKTSI ICAFLFSLIP TLMFINSGYD
70 80 90 100 110 120
MIISNWHWMT IQTLNLTMSF KMDMFSMMFV PVALFVTWSI MEFSLWYMHS DPYINRFFKY
130 140 150 160 170 180
LLLFLITMII LVTANNLFQL FIGWEGVGIM SFLLIGWWYG RPDANTAALQ AVLYNRIGDI
190 200 210 220 230 240
GFVLSMAWFL MHSSSWEFQQ RFSSQNSSNI LPLLGLILAA AGKSAQFGLH PWLPSAMEGP
250 260 270 280 290 300
TPVSALLHSS TMVVAGVFLL IRFYPFIKNN QLVQSIIMCL GAITTLFTAI CALTQNDIKK
310 320 330 340 350 360
IIAFSTSSQL GLMMVTIGIN QPYLAFFHIC THAFFKAMLF MCSGSIIHNL NDEQDIRKMG
370 380 390 400 410 420
GLFKTLPFTS SELTVGSLTL TGTPYLTGFY SKDLIIESAN TSYTNAWALS ITLIATSLTA
430 440 450 460 470 480
IYSTRIIFLL IRSKPRFVPL SPINENNPLL NNAIKRLLIG SIFAGFLITN NMTPMSIQQM
490 500 510 520 530 540
TMPWYLKLTA LIVTILGFMM AMELNNLSLY FKYKTTSQHV KFSNLLGFFP STMHRLFPNT
550 560 570 580 590 600
NLLISHNSAS TLLDLIWLEK STPKLLSSTQ LMDSTLSSNQ TGLIKLYFLS FLLSMLMVTM
LII