O62806

PR
Gene name
MMP13
Protein name
Collagenase 3
Names
IL-2 receptor subunit alpha, IL-2-RA, IL-2R subunit alpha, IL2-RA, TAC antigen, p55, Matrix metalloproteinase-13, MMP-13
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100008685
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-93 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O62806

Entry ID Method Resolution Chain Position Source
AF-O62806-F1 Predicted AlphaFoldDB

No variants for O62806

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O62806

No associated diseases with O62806

No regional properties for O62806

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O62806

Functions

Description
EC Number
Subcellular Localization
  • Secreted, extracellular space, extracellular matrix
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
extracellular matrix A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

5 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
collagen binding Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
zinc ion binding Binding to a zinc ion (Zn).

4 GO annotations of biological process

Name Definition
bone morphogenesis The process in which bones are generated and organized.
collagen catabolic process The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.
extracellular matrix disassembly A process that results in the breakdown of the extracellular matrix.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQPGVLAACL LLSWTHCWSL PLLNSNEDDD LSEEDFQFAE SYLRSYYHPL NPAGILKKNA
70 80 90 100 110 120
AGSMVDRLRE MQSFFGLEVT GKLDDNTLAI MKQPRCGVPD VGEYNVFPRT LKWSQTNLTY
130 140 150 160 170 180
RIVNYTPDLT HSEVEKAFKK AFKVWSDVTP LNFTRIHNGT ADIMISFGTK EHGDFYPFDG
190 200 210 220 230 240
PSGLLAHAFP PGPNYGGDAH FDDDETWTSS SKGYNLFLVA AHEFGHSLGL DHSKDPGALM
250 260 270 280 290 300
FPIYTYTGKS HFMLPDDDVQ GIQSLYGPGD EDPNPKHPKT PDKCDPSLSL DAITSLRGET
310 320 330 340 350 360
MIFKDRFFWR LHPQQVDAEL FLTKSFWPEL PNRIDAAYEH PARDLIFIFR GKKFWAPNGY
370 380 390 400 410 420
DILEGYPQKL SELGFPREVK KISAAVHFED TGKTLFFSGN QVWSYDDTNH TMDQDYPRLI
430 440 450 460 470
EEEFPGIGGK VDAVYEKNGY IYFFNGPIQF EYSIWSKRIV RVMPTNSLLW C