O62301
Gene name |
smg-8 (K04B12.3) |
Protein name |
Nonsense-mediated mRNA decay factor SMG8 |
Names |
Suppressor with morphogenetic effect on genitalia protein 8 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_K04B12.3 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for O62301
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5NKK | X-ray | 264 A | A/C/E | 1-423 | PDB |
| 5NKM | X-ray | 249 A | PDB | ||
| AF-O62301-F1 | Predicted | AlphaFoldDB |
No variants for O62301
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O62301 | |||||
No associated diseases with O62301
No regional properties for O62301
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O62301 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| striated muscle dense body | A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDIAKWVEHA | RTCYSTQLDT | KIKVIGVIGK | DYPDHGKGDN | INCYLRENVF | PVAATEDETC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TIRGHFSEDD | QILFLVMNGV | DDVANIRKCL | KSNPKSNYFD | AMAESECQQI | RMLHFLFISC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HFIIIFEQTS | RIDLELMRFL | KKVNSARIQL | RKKINQRLVA | SDLRDVSFNN | RILSSAESEG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RMVVPRLLIA | FQRNNIRPDV | NPGKKLQREL | YEKLEKNLDN | QFSDILKLYD | LIDCGASSLC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QLNETIPVVH | LLNPKIVKRD | IIGEMFEILM | ADAENTKISG | NAGTLPSNNS | FVKFLEDNFR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SEKNEISLEN | VIELMNCLQC | VLDGDLEEKH | EKTAIQTFIK | RIQNDHMEEA | RRLYTNAQRP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GERRGADRFK | DSEKPVKIRS | KEEHLMRFNE | ATHYIDSVVG | VNSREALSQL | QAQCNEMWQS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DMRACESVSM | MGRSCVRKIH | PTFGDQTAPE | HRWTAHDASN | TMISTCVCGR | KQLIRPEPFS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VKEANSDFYD | HPDFKCCRRL | WRYQFQLYQE | DSEEKDDIMW | ADRESNSLRA | AKKMAQREDE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LAEEDTDLDI | PESLLDPDST | SPSDEDDVRV | RTMSSSESSS | QESDAYLRPT | SRRDESMASK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TERELTIDHV | KRMQKLELAG | KSEDFLITVP | NSMTTGKLPI | FPSWHLTSLG | DSSIYSHGAG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LKNQPNFKIG | GDYLSPVVVL | LDVNFDVWNR | DLNKIRSEDF | SRKCGKDNKD | DSARVKLFVG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| FEYECSRGHR | FFVDYNGEPL | IYSKGSNVIR | ESAHRSSLGN | VLQADLPIRR | PCTCRKLPLQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SAQLQKVHVV | TPKAPVHITI | DPKVLIPTHE | GVYGTGQEPL | ELHHSKYYIL | HLPTVYSGPS |
| 850 | 860 | 870 | |||
| GAWMPGEFNP | EKQGVWMGGA | LKVAYKPVMS | FKW |