Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O61585
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O61585-F1 | Predicted | AlphaFoldDB |
No variants for O61585
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O61585 | |||||
No associated diseases with O61585
8 regional properties for O61585
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 5 - 262 | IPR001680 |
| conserved_site | WD40 repeat, conserved site | 116 - 130 | IPR019775-1 |
| conserved_site | WD40 repeat, conserved site | 158 - 172 | IPR019775-2 |
| conserved_site | WD40 repeat, conserved site | 200 - 214 | IPR019775-3 |
| repeat | G-protein beta WD-40 repeat | 116 - 130 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 158 - 172 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 200 - 214 | IPR020472-3 |
| domain | Katanin p80 subunit, C-terminal | 529 - 686 | IPR028021 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| katanin complex | A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa). |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
| spindle pole | Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| microtubule binding | Binding to a microtubule, a filament composed of tubulin monomers. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| microtubule depolymerization | The removal of tubulin heterodimers from one or both ends of a microtubule. |
| microtubule severing | The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATKRAWKLQ | ELVAHSSNVN | CLALGPMSGR | VMVTGGEDKK | VNLWAVGKQN | CIISLSGHTS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PVDSVKFNSS | EELVVAGSQS | GTMKIYDLEP | AKIVRTLTGH | RNSIRCMDFH | PFGEFVASGS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TDTNVKLWDV | RRKGCIYTYK | GHSDQVNMIK | FSPDGKWLVT | ASEDTTIKLW | DLTMGKLFQE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FKNHTGGVTG | IEFHPNEFLL | ASGSSDRTVQ | FWDLETFQLV | SSTSPGASAV | RSISFHPDGS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YLFCSSQDML | HAFGWEPIRC | FDTFSVGWGK | VADTVIASTQ | LIGASFNATN | VSVYVADLSR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MSTTGIAQEP | QSQPSKTPSG | GAEEVPSKPL | TASGRKNFVR | ERPHTTSSKQ | RQPDVKSEPE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RQSPTQDEGV | KDDDATDIKD | PDSYAKIFSP | KTRVDHSPER | NAQPFPAPLD | VPGAQEPEPF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KHPPKPAAAA | AVAPVSRAPA | PSASDWQPAQ | ANPAPNRVPA | ATKPVPAQEV | APSRKPDPIS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TIIPSDRNKP | ANLDMDAFLP | PAHAQQAPRV | NAPASRKQSD | SERIEGLRKG | HDSMCQVLSS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RHRNLDVVRA | IWTAGDAKTS | VESVVNMKDQ | AILVDILNIM | LLKKSLWNLD | MCVVVLPRLK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ELLSSKYENY | VHTSCACLKL | ILKNFTSLFN | QNIKCPPSGI | DITREERYNK | CSKCYSYLIA |
| 670 | 680 | ||||
| TRGYVEEKQH | VSGKLGSSFR | ELHLLLDQLE |