O61125

PR
Gene name
krsA (krs1, DDB_G0284181)
Protein name
Serine/threonine-protein kinase 4 homolog A
Names
Kinase responsive to stress A, STE20-like kinase krsA
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0284181
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

268-461 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

156-179 (Activation loop from InterPro)

Target domain

20-273 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for O61125

Entry ID Method Resolution Chain Position Source
AF-O61125-F1 Predicted AlphaFoldDB

No variants for O61125

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O61125

No associated diseases with O61125

3 regional properties for O61125

Type Name Position InterPro Accession
domain Protein kinase domain 20 - 273 IPR000719
domain SARAH domain 411 - 458 IPR011524
binding_site Protein kinase, ATP binding site 26 - 50 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

9 GO annotations of biological process

Name Definition
aggregation involved in sorocarp development The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.
hyperosmotic response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation The process of introducing a phosphate group on to a protein.
protein tetramerization The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway.
regulation of MAPK cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTLNVPKET MSRKDPEKFF TIVEKLGEGS YGSVYKAINI STGIVVAIKK VSVDNDLEDM
70 80 90 100 110 120
EKEISFMKQC KSPYIVTYYA SFRKENEVWI VMEHCGAGSV CDAMKITDKT LSEDQIAVVS
130 140 150 160 170 180
RDVLQGLAYL HSVRKIHRDI KAGNILMNHK GESKLADFGV SGQLSDTMAK RQTVIGTPFW
190 200 210 220 230 240
MAPEVIQEIG YDYKADIWSY GITCIEMAES KPPLFNVHPM RVIFMIPNPS RPPPKLTEPE
250 260 270 280 290 300
KWSPEFNDFL AKCLTRKPEL RPSAEELLKH PFITKAKSHS LLVPLIDEQD IIINEKGREV
310 320 330 340 350 360
ALGIEQRDEE EEDEDEDSED SDDNRGTMVR AKPRSMQNSG GEDNDEEYDT GTMVITDNKN
370 380 390 400 410 420
SYDTVVFNND DEDSGTMKLK NTMPSNKKNF VPDYMNQFKK SDDDVTNVPL SDKYSSYSLE
430 440 450 460
ELKKMLAELE IEREKEVQKT LEKFSINRQA LLAVIDEKKS K