O61122

PR
Gene name
svkA (DDB_G0286359)
Protein name
Serine/threonine-protein kinase svkA
Names
Severin kinase A
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0286359
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

285-444 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

149-172 (Activation loop from InterPro)

Target domain

12-262 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for O61122

Entry ID Method Resolution Chain Position Source
AF-O61122-F1 Predicted AlphaFoldDB

No variants for O61122

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O61122

No associated diseases with O61122

No regional properties for O61122

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O61122

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm, cytosol
  • Nucleus
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Cytoplasm, cytoskeleton, spindle
  • Cleavage furrow
  • Shows overall localization in the cytosol and, to a lesser extent, in the nucleus
  • Enriched around the centrosome
  • In dividing cells, forms a cloud around the spindle and nuclei
  • Enriched in the cleavage furrow during late cytokinesis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cleavage furrow The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitotic spindle A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

10 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
hippo signaling The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.
hyperosmotic response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
positive regulation of cell division Any process that activates or increases the frequency, rate or extent of cell division.
positive regulation of mitotic cytokinetic process Any process that activates or increases the frequency, rate or extent of mitotic cytokinetic process.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of sorocarp development Any process that modulates the frequency, rate or extent of sorocarp development. An example of this process is found in Dictyostelium discoideum.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASKKGDPEE LYVRQEKIGK GSFGEVFKGI NKKTNETIAI KTIDLEDAED EIEDIQQEIN
70 80 90 100 110 120
VLSQCESPFV TKYFGSFLKG SKLWIIMEYL AGGSVLDLMK PGPFDEGYIA IILRELLKGL
130 140 150 160 170 180
EYLHSEGKIH RDIKAANVLL SASGDVKLAD FGVSGQLTDQ MTKRNTFVGT PFWMAPEVIK
190 200 210 220 230 240
QTGYDSKADI WSMGITALEM AKGEPPRADL HPMRALFLIP KDPPPTLEGN FSKGFKEFCA
250 260 270 280 290 300
LCLNKDPNQR PTAKDLLKHK FIKAAKKTSS LTDLIERRQK WLQLNGNNAD DENDDLDRDA
310 320 330 340 350 360
KSNEEDFGWE FPTIKQKSPV AVQEQQQTPQ KPTVVSTPIK EQQQQQQPTP VTTPQQPVTT
370 380 390 400 410 420
TTTTPTTETK VRSLSNSSQT TPVKTTVAAT TAPATTPASN APTSTTPNGA AVTQQQAPRA
430 440 450 460 470
SALTSVIYPV LSKLLKNTSD ENVINALAQL KMAFDNAEKA KPGITHSLIA QIIETLKR