AiPD: Autoinhibited Protein Database

O60921

Gene name	HUS1
Protein name	Checkpoint protein HUS1
Names	hHUS1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3364
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

126-261 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

126-261 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

8 structures for O60921

Entry ID	Method	Resolution	Chain	Position	Source
3A1J	X-ray	250 A	B	1-280	PDB
3G65	X-ray	290 A	C	1-280	PDB
3GGR	X-ray	320 A	B	2-280	PDB
6J8Y	X-ray	240 A	B	2-280	PDB
7Z6H	EM	359 A	C	1-280	PDB
8GNN	X-ray	212 A	B	2-280	PDB
8WU8	X-ray	281 A	B	2-280	PDB
AF-O60921-F1	Predicted				AlphaFoldDB

243 variants for O60921

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA158098520 rs565968847	4	R>Q		No	ClinGen 1000Genomes TOPMed gnomAD
CA4254838 rs138248432	4	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs929255655 CA158098514	5	A>T		No	ClinGen TOPMed
rs1290243825 CA367478240	6	K>E		No	ClinGen gnomAD
rs2307255 CA158098513	7	I>V		No	ClinGen TOPMed gnomAD
rs1296244296 CA367478161	8	V>M		No	ClinGen TOPMed gnomAD
rs762826065 CA4254834	9	D>E		No	ClinGen ExAC gnomAD
CA367478137 rs1467385363	9	D>N		No	ClinGen gnomAD
rs202090804 CA367478102 CA367478097	10	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs764942406 CA4254832	10	G>V		No	ClinGen ExAC gnomAD
rs202090804 CA4254833	10	G>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367478077 rs1413572646	11	A>P		No	ClinGen gnomAD
rs761731324 CA4254831	11	A>V		No	ClinGen ExAC gnomAD
TCGA novel	12	C>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367478049 rs1473213789	12	C>S		No	ClinGen gnomAD
CA367478005 rs1395968010	13	L>R		No	ClinGen gnomAD
rs973250941 CA158098468	14	N>K		No	ClinGen TOPMed
rs746474307 CA367477958	15	H>P		No	ClinGen ExAC gnomAD
CA4254827 rs746474307	15	H>R		No	ClinGen ExAC gnomAD
rs145887588 CA4254828	15	H>Y		No	ClinGen ESP ExAC TOPMed
rs1353488841 CA367477922	16	F>L		No	ClinGen TOPMed
CA367476894 rs1163411332	20	S>C		No	ClinGen TOPMed gnomAD
CA4254802 rs755310110	20	S>N		No	ClinGen ExAC gnomAD
rs1583726906 CA367476881	20	S>R		No	ClinGen Ensembl
rs1189431144 CA367476840	23	I>T		No	ClinGen gnomAD
rs1364238179 CA367476832	24	A>T		No	ClinGen TOPMed
rs1421260438 CA367476814	25	K>R		No	ClinGen TOPMed
CA367476795 rs780317696	27	A>P		No	ClinGen ExAC TOPMed gnomAD
CA367476794 rs780317696	27	A>S		No	ClinGen ExAC TOPMed gnomAD
rs780317696 CA4254800	27	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4254799 rs758455511	29	T>I		No	ClinGen ExAC gnomAD
rs778688123 CA4254797	30	C>G		No	ClinGen ExAC gnomAD
CA367476749 rs1304081753	30	C>Y		No	ClinGen TOPMed
CA367476726 rs1243581487	31	T>S		No	ClinGen gnomAD
CA4254794 rs763893952	32	L>V		No	ClinGen ExAC TOPMed gnomAD
CA4254792 rs752394885	33	R>C		No	ClinGen ExAC TOPMed gnomAD
rs554018144 CA367476699	33	R>H		No	ClinGen gnomAD
CA158097965 rs554018144	33	R>P		No	ClinGen gnomAD
rs1015917843 CA367476642	35	S>I		No	ClinGen TOPMed gnomAD
rs1015917843 CA158097956	35	S>N		No	ClinGen TOPMed gnomAD
CA4254790 rs759095619	35	S>R		No	ClinGen ExAC TOPMed gnomAD
rs773958274 CA4254789	36	P>S		No	ClinGen ExAC TOPMed gnomAD
CA367476601 rs1423186911	37	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA4254787 rs28910274	43	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200244554 CA4254786	44	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1201163815 CA367476399	45	D>A		No	ClinGen gnomAD
rs572690669 CA4254785	46	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1312515924 CA367476341	48	A>T		No	ClinGen gnomAD
rs1251131745 CA367476315	49	N>D		No	ClinGen TOPMed
CA4254782 rs780223767	49	N>S		No	ClinGen ExAC gnomAD
rs780223767 CA4254783	49	N>T		No	ClinGen ExAC gnomAD
rs11551144 CA158097894	54	M>V		No	ClinGen Ensembl
CA367476149 rs1441417649	56	C>W		No	ClinGen TOPMed
CA367476065 rs1275099670	60	Q>H		No	ClinGen TOPMed gnomAD
rs1176574912 CA367476067	60	Q>L		No	ClinGen TOPMed
rs771041168 CA4254756	61	E>K		No	ClinGen ExAC TOPMed gnomAD
rs749387979 CA367475981	62	N>D		No	ClinGen ExAC gnomAD
CA4254755 rs749387979	62	N>Y		No	ClinGen ExAC gnomAD
rs1467698553 CA367475952	63	F>L		No	ClinGen TOPMed
CA4254752 rs1554293188	65	N>H		No	ClinGen Ensembl
rs1408682972 CA367475921	66	E>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1408682972 CA367475923	66	E>K		No	ClinGen TOPMed gnomAD
CA4254750 rs142407794	68	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs781076158 CA4254748	69	M>T		No	ClinGen ExAC TOPMed gnomAD
rs748118434 CA4254749	69	M>V		No	ClinGen ExAC TOPMed gnomAD
CA4254747 rs754824991	71	G>S		No	ClinGen ExAC TOPMed gnomAD
CA4254746 rs751218600	71	G>V		No	ClinGen ExAC gnomAD
rs1210122585 CA367475876	72	V>A		No	ClinGen gnomAD
CA367475881 rs1240868920	72	V>I		No	ClinGen TOPMed gnomAD
CA4254744 rs757900445	73	S>A		No	ClinGen ExAC gnomAD
rs749937055 CA4254743	74	A>T		No	ClinGen ExAC TOPMed gnomAD
rs570029976 CA4254741 CA367475844	77	N>K		No	ClinGen 1000Genomes ExAC gnomAD
CA4254742 rs371092744	77	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA158097731 rs995696177	78	E>A		No	ClinGen Ensembl
rs879014099 CA158097727	80	Y>C		No	ClinGen gnomAD
CA367475813 rs1334936728	82	E>*		No	ClinGen gnomAD
CA4254738 rs202060328	85	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs202060328 CA4254739	85	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs201091914 CA4254736	86	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA158097705 rs890857470	89	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA367475767 rs890857470	89	S>Y		No	ClinGen TOPMed gnomAD
CA4254735 rs567292691	90	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA4254734 rs773375727	90	R>P		No	ClinGen ExAC gnomAD
rs548696788 CA367475735	95	A>P		No	ClinGen TOPMed
rs548696788 CA158097697	95	A>S		No	ClinGen TOPMed
rs149049902 CA4254732	101	L>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA367475686 rs1342494080	102	K>R		No	ClinGen TOPMed
CA158097679 rs1051302184	103	I>V		No	ClinGen Ensembl
CA367475672 rs1383042472	104	K>R		No	ClinGen TOPMed gnomAD
CA367475658 rs932448154	106	T>I		No	ClinGen gnomAD
CA158097664 rs932448154	106	T>S		No	ClinGen gnomAD
CA367475657 rs1462366176	107	N>H		No	ClinGen gnomAD
CA367475653 rs1485961031	107	N>S		No	ClinGen gnomAD
rs901750458 CA158097657	109	H>P		No	ClinGen TOPMed gnomAD
CA367475639 rs1277589872	109	H>Y		No	ClinGen TOPMed
rs899482012 CA158097653	110	F>L		No	ClinGen Ensembl
CA367475626 rs1445836673	111	P>A		No	ClinGen TOPMed gnomAD
rs200875322 CA4254730	111	P>H		No	ClinGen 1000Genomes ExAC gnomAD
CA367475625 rs1445836673	111	P>S		No	ClinGen TOPMed gnomAD
CA367475627 rs1445836673	111	P>T		No	ClinGen TOPMed gnomAD
rs1359145415 CA367475617	112	C>F		No	ClinGen gnomAD
CA4254728 rs746826153	113	L>F		No	ClinGen ExAC TOPMed gnomAD
rs779721301 CA4254727	114	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4254725 rs750116033	116	S>A		No	ClinGen ExAC gnomAD
rs768071524 CA4254721	117	V>E		No	ClinGen ExAC gnomAD
CA4254722 rs753201633	117	V>L		No	ClinGen ExAC TOPMed gnomAD
CA367475593 rs753201633	117	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs774619687 CA4254719	118	E>D		No	ClinGen ExAC gnomAD
rs759924524 CA4254720	118	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1325875533 CA367474824	120	L>S		No	ClinGen gnomAD
rs761951127 CA4254693	121	S>P		No	ClinGen ExAC TOPMed gnomAD
rs761951127 CA367474820	121	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1309010889 CA367474794	122	M>I		No	ClinGen TOPMed
CA158096348 rs769565341	122	M>T		No	ClinGen Ensembl
CA367474811 rs1296106302	122	M>V		No	ClinGen TOPMed
CA367474770 rs1272603961	124	S>N		No	ClinGen TOPMed gnomAD
CA4254691 rs768800136	125	S>R		No	ClinGen ExAC gnomAD
rs2307261 CA4254690 VAR_033999	126	S>G		No	ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD
CA4254689 rs368138281	127	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs990421342 CA158096333	127	R>H		No	ClinGen TOPMed gnomAD
rs990421342 CA367474722	127	R>L		No	ClinGen TOPMed gnomAD
TCGA novel	128	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745724153 CA4254688	128	I>S		No	ClinGen ExAC TOPMed gnomAD
rs745724153 CA4254687	128	I>T		No	ClinGen ExAC TOPMed gnomAD
rs963026262 CA158096318	128	I>V		No	ClinGen Ensembl
CA4254686 rs778515951	130	T>S		No	ClinGen ExAC gnomAD
CA158096311 rs983371620	131	H>R		No	ClinGen Ensembl
CA4254685 rs770612941	132	D>N		No	ClinGen ExAC gnomAD
CA4254684 rs374782041	133	I>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA367474650 rs1406282119	133	I>V		No	ClinGen gnomAD
rs370417384 CA4254683	134	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs370417384 CA367474628	134	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1161884207 CA367474604	136	K>R		No	ClinGen TOPMed gnomAD
TCGA novel	144	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780666620 CA4254680	144	K>T		No	ClinGen ExAC
rs758666500 CA4254679	145	D>G		No	ClinGen ExAC gnomAD
rs2307254 CA367474441	147	Q>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs2307254 CA367474444	147	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_025414 rs2307254 CA4254678	147	Q>K		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA367474436 rs1203161065	147	Q>L		No	ClinGen gnomAD
CA4254677 rs765725449	149	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	150	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367474351 rs1316203636	154	P>A		No	ClinGen TOPMed gnomAD
CA367474350 rs1316203636	154	P>T		No	ClinGen TOPMed gnomAD
CA367474343 rs1247881572	155	D>N		No	ClinGen gnomAD
CA4254652 rs752863886	157	S>I		No	ClinGen ExAC gnomAD
rs756128834 CA4254653	157	S>R		No	ClinGen ExAC gnomAD
CA367474221 rs1428560343	158	I>M		No	ClinGen gnomAD
rs767526776 CA4254651	158	I>N		No	ClinGen ExAC TOPMed gnomAD
CA158095483 rs767526776	158	I>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	158	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA158095482 rs993645749	160	L>*		No	ClinGen Ensembl
rs759420995 CA4254650	160	L>F		No	ClinGen ExAC gnomAD
rs774286190 CA4254649	161	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1562590048 CA367474073	165	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA4254647 rs762795092	166	M>T		No	ClinGen ExAC gnomAD
CA4254648 rs139623972	166	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs772715878 CA4254646	167	K>E		No	ClinGen ExAC gnomAD
CA158095447 rs963706140	167	K>N		No	ClinGen TOPMed gnomAD
rs769525580 CA4254645	168	S>T		No	ClinGen ExAC TOPMed gnomAD
CA367473954 rs1460468394	170	V>M		No	ClinGen gnomAD
CA367473844 rs1260649152	173	M>I	Variant assessed as Somatic; 4.631e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	173	M>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA158095426 rs1018212456	173	M>T		No	ClinGen TOPMed
rs901600537 CA158095418	175	N>T		No	ClinGen TOPMed gnomAD
CA158095384 rs375639721	176	I>T		No	ClinGen TOPMed
rs776155080 CA4254643	176	I>V		No	ClinGen ExAC gnomAD
rs758303126 CA4254610	181	V>I		No	ClinGen ExAC gnomAD
rs1476660827 CA367474284	182	I>V		No	ClinGen gnomAD
rs1374205743 CA367474243	184	A>G		No	ClinGen gnomAD
CA158124480 rs1046961710	185	N>K		No	ClinGen TOPMed
CA4254608 rs765013904	188	G>R		No	ClinGen ExAC gnomAD
CA4254606 rs763890469	192	L>F		No	ClinGen ExAC gnomAD
rs138848570 CA367474067	196	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs138848570 CA4254604	196	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs771730666 CA4254602	199	V>L		No	ClinGen ExAC TOPMed gnomAD
rs761654334 CA158124374	200	C>R		No	ClinGen gnomAD
CA4254601 rs763461631	200	C>S		No	ClinGen ExAC gnomAD
rs773598798 CA4254600	203	T>N		No	ClinGen ExAC gnomAD
rs1237795972 CA367473913	207	D>N		No	ClinGen gnomAD
CA367473877 rs575534013	209	G>A		No	ClinGen 1000Genomes ExAC gnomAD
CA4254599 rs575534013	209	G>E		No	ClinGen 1000Genomes ExAC gnomAD
rs1462690540 CA367473862	210	N>K		No	ClinGen gnomAD
rs1042435792 CA158124359	210	N>S		No	ClinGen gnomAD
rs1263777627 CA367473852	211	P>L		No	ClinGen gnomAD
rs748508349 CA4254598	212	P>L		No	ClinGen ExAC gnomAD
CA4254597 rs781361344	213	L>*		No	ClinGen ExAC TOPMed gnomAD
rs1306763036 CA367473493	215	S>F		No	ClinGen gnomAD
rs1198579054 CA367473464	219	H>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA367473466 rs1198579054	219	H>R		No	ClinGen TOPMed gnomAD
VAR_025415 CA4254580 rs3176588	221	D>E		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs752411443 CA4254581	221	D>Y		No	ClinGen ExAC gnomAD
rs759036115 CA4254579	223	N>S		No	ClinGen ExAC TOPMed gnomAD
rs765701835 CA4254577	224	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1217424557 CA367473427	225	E>Q		No	ClinGen gnomAD
CA158122860 rs776350827	226	H>R		No	ClinGen gnomAD
rs762413622 CA4254576	227	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1420788573 CA367473400	228	A>V		No	ClinGen gnomAD
rs200031230 CA4254575	229	E>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA367473369 rs1386091463	232	I>K		No	ClinGen gnomAD
CA4254574 rs769018345	232	I>L		No	ClinGen ExAC gnomAD
CA4254573 rs548463200	232	I>M		No	ClinGen 1000Genomes ExAC gnomAD
CA4254572 rs775753755	233	D>G		No	ClinGen ExAC gnomAD
CA4254571 rs772175797	234	I>T		No	ClinGen ExAC TOPMed gnomAD
CA158122835 rs565803246	234	I>V		No	ClinGen Ensembl
rs369947303 CA4254570	236	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1487885002 CA367473325	237	L>F		No	ClinGen TOPMed gnomAD
CA4254569 CA367473310 rs528436783	239	Q>H		No	ClinGen 1000Genomes ExAC gnomAD
rs1283642678 CA367473313	239	Q>P		No	ClinGen TOPMed gnomAD
rs1283642678 CA367473312	239	Q>R		No	ClinGen TOPMed gnomAD
CA4254568 rs757107208	240	F>L		No	ClinGen ExAC gnomAD
rs1264458856 CA367473303	240	F>L		No	ClinGen gnomAD
CA4254567 rs749261354	242	A>D		No	ClinGen ExAC gnomAD
CA367473291 rs1295626546	243	G>R		No	ClinGen gnomAD
CA367473283 rs1340390102	244	Q>*		No	ClinGen gnomAD
rs1229068224 CA367473265	246	V>A		No	ClinGen TOPMed
CA4254563 rs752394896	249	T>I		No	ClinGen ExAC gnomAD
rs372086665 CA158122759	250	K>E		No	ClinGen ESP
rs369406174 CA4254561	252	L>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA4254562 rs79656108	252	L>I		No	ClinGen ExAC gnomAD
rs199759985 CA4254560	253	C>R		No	ClinGen 1000Genomes ExAC gnomAD
CA158120395 rs769754613	254	N>S		No	ClinGen Ensembl
rs751237091 CA4254539	255	I>T		No	ClinGen ExAC gnomAD
CA367472983 rs1439251228	256	V>A		No	ClinGen gnomAD
CA367472987 rs1196408323	256	V>L		No	ClinGen gnomAD
CA4254538 rs779360913	260	M>V		No	ClinGen ExAC gnomAD
CA367472927 rs1197514781	261	V>L		No	ClinGen TOPMed gnomAD
rs1197514781 CA367472930	261	V>M		No	ClinGen TOPMed gnomAD
CA4254537 rs200372941	266	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1264418418 CA367472871	266	L>P		No	ClinGen gnomAD
rs1346260670 CA367472861	267	H>L		No	ClinGen gnomAD
rs754327169 CA4254536	267	H>N		No	ClinGen ExAC gnomAD
CA4254534 rs553523764	269	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4254535 rs10253916	269	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4254532 rs767949931	270	V>L		No	ClinGen ExAC gnomAD
CA367472833 rs767949931	270	V>M		No	ClinGen ExAC gnomAD
CA4254530 rs774639525	272	L>F		No	ClinGen ExAC TOPMed gnomAD
rs774639525 CA4254531	272	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1446254392 CA367472809	273	Q>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs771131844 CA4254529	274	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA367472751 rs1379315871	278	A>P		No	ClinGen TOPMed
rs763185314 CA4254527	278	A>V		No	ClinGen ExAC TOPMed gnomAD
CA367472738 rs1373060579	279	L>Q		No	ClinGen TOPMed

No associated diseases with O60921

No regional properties for O60921

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O60921

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm, cytosol	In discrete nuclear foci upon DNA damage (PubMed:11077446) According to PubMed:11077446, localized also in the cytoplasm (PubMed:11077446) DNA damage induces its nuclear translocation (PubMed:11077446) Shuttles between the nucleus and the cytoplasm (PubMed:11077446)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
checkpoint clamp complex	Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
site of double-strand break	A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

14 GO annotations of biological process

Name	Definition
cellular response to DNA damage stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
cellular response to ionizing radiation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
DNA damage checkpoint signaling	A signal transduction process that contributes to a DNA damage checkpoint.
DNA repair	The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
double-strand break repair via homologous recombination	The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
embryo development ending in birth or egg hatching	The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
meiotic DNA integrity checkpoint signaling	A signal transduction process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during meiosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction.
mitotic DNA replication checkpoint signaling	A signal transduction process that contributes to a mitotic DNA replication checkpoint.
mitotic intra-S DNA damage checkpoint signaling	A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
nucleotide-excision repair	A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of protein phosphorylation	Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
response to UV	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
telomere maintenance	Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8NHY5	HUS1B	Checkpoint protein HUS1B	Homo sapiens (Human)	PR
Q8K572	Hus1b	Checkpoint protein HUS1B	Mus musculus (Mouse)	PR
Q8BQY8	Hus1	Checkpoint protein HUS1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MKFRAKIVDG	ACLNHFTRIS	NMIAKLAKTC	TLRISPDKLN	FILCDKLANG	GVSMWCELEQ
70	80	90	100	110	120
ENFFNEFQME	GVSAENNEIY	LELTSENLSR	ALKTAQNARA	LKIKLTNKHF	PCLTVSVELL
130	140	150	160	170	180
SMSSSSRIVT	HDIPIKVIPR	KLWKDLQEPV	VPDPDVSIYL	PVLKTMKSVV	EKMKNISNHL
190	200	210	220	230	240
VIEANLDGEL	NLKIETELVC	VTTHFKDLGN	PPLASESTHE	DRNVEHMAEV	HIDIRKLLQF
250	260	270
LAGQQVNPTK	ALCNIVNNKM	VHFDLLHEDV	SLQYFIPALS