AiPD: Autoinhibited Protein Database

O60667

Gene name	FCMR
Protein name	Fas apoptotic inhibitory molecule 3
Names	IgM Fc fragment receptor, Regulator of Fas-induced apoptosis Toso
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9214
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

260-355 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

260-355 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

8 structures for O60667

Entry ID	Method	Resolution	Chain	Position	Source
7YSG	EM	318 A	R/S/U/V	18-124	PDB
7YTC	EM	339 A	R	18-124	PDB
7YTD	EM	371 A	R/S/U/V	18-124	PDB
7YTE	X-ray	300 A	C/D	18-124	PDB
8BPE	EM	363 A	I/M/N/O/P/Q/R/S	18-251	PDB
8BPF	EM	350 A	I	18-251	PDB
8BPG	EM	310 A	A/B	18-251	PDB
AF-O60667-F1	Predicted				AlphaFoldDB

322 variants for O60667

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA344494812 rs1350151656	2	D>G		No	ClinGen gnomAD
rs114123219 CA1364871	3	F>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1364870 rs757911655	4	W>*		No	ClinGen ExAC gnomAD
CA1364869 rs147642736	5	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764899080 CA1364868	6	W>*		No	ClinGen ExAC gnomAD
rs759853868 CA344494774	8	L>I		No	ClinGen ExAC gnomAD
CA1364867 rs759853868	8	L>V		No	ClinGen ExAC gnomAD
CA344494763 rs1558007468	9	Y>*		No	ClinGen Ensembl
rs1414899770 CA344494747	12	P>A		No	ClinGen gnomAD
CA1364865 rs552102761	13	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1297375893 CA344492211	14	S>L		No	ClinGen gnomAD
CA1364832 rs770859702	16	A>D		No	ClinGen ExAC gnomAD
CA1364833 rs775505567	16	A>S		No	ClinGen ExAC TOPMed gnomAD
rs777892635 CA1364830	21	P>R		No	ClinGen ExAC gnomAD
rs140166670 CA1364828	22	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs778545589 CA1364827	25	V>A		No	ClinGen ExAC gnomAD
rs778545589 CA344492019	25	V>G		No	ClinGen ExAC gnomAD
rs754442724 CA1364826	26	E>D		No	ClinGen ExAC TOPMed gnomAD
CA1364825 rs753534621	28	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs779983414	28	E>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	29	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1264898267 CA344491948	29	L>V		No	ClinGen TOPMed
rs1199005341 CA344491932	30	G>R		No	ClinGen TOPMed
CA1364819 rs762438219	31	G>E		No	ClinGen ExAC gnomAD
rs200811923 CA1364820 CA1364821	31	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA344491851 rs1273448087	34	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA1364818 rs770987820	35	I>F		No	ClinGen ExAC gnomAD
CA36566421 rs770987820	35	I>V		No	ClinGen ExAC gnomAD
CA344491821 rs1309666043	36	K>M		No	ClinGen gnomAD
rs762880718 CA344491741	40	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs762880718 CA1364816	40	P>T		No	ClinGen ExAC gnomAD
rs1393194498 CA344491682	42	M>I		No	ClinGen TOPMed
CA36566398 rs991913284	42	M>T		No	ClinGen TOPMed
CA344491661 rs1277667664	43	H>Q		No	ClinGen TOPMed
rs1356627251 CA344491658	44	V>M		No	ClinGen gnomAD
CA36566376 rs958676725	45	R>K		No	ClinGen TOPMed gnomAD
CA344491617 rs1369966667	46	I>L		No	ClinGen gnomAD
rs139493002 CA344491608	46	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA1364814 rs144545406	46	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA1364811 rs538577206	50	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA344491545 rs370696168	50	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1373934644 CA344491508	52	M>L		No	ClinGen gnomAD
CA1364807 rs774091460	55	S>C		No	ClinGen ExAC gnomAD
CA344491431 rs1249164453	56	G>E		No	ClinGen gnomAD
rs768225740 CA1364806	56	G>R		No	ClinGen ExAC gnomAD
CA344491404 rs1481399347	58	C>R		No	ClinGen gnomAD
rs781602626 CA1364801	61	V>A		No	ClinGen ExAC gnomAD
COSM1251690 rs981290107 CA36566297	61	V>M	oesophagus [Cosmic]	No	ClinGen cosmic curated gnomAD
rs757494473 CA1364800	63	S>F		No	ClinGen ExAC gnomAD
CA1364799 rs752118035	65	T>A		No	ClinGen ExAC TOPMed gnomAD
rs967220083 CA36566250	65	T>I		No	ClinGen gnomAD
rs967220083 CA344491298	65	T>N		No	ClinGen gnomAD
rs764455584 CA344491272	66	N>K		No	ClinGen ExAC gnomAD
CA36566228 rs1020537472	69	K>E		No	ClinGen Ensembl
rs1291634581 CA344491199	70	A>V		No	ClinGen gnomAD
CA1364797 rs758532665	75	R>*		No	ClinGen ExAC TOPMed gnomAD
COSM532176 rs373086444 CA1364796 COSM1648464	75	R>Q	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs765390434 CA1364795	78	L>V		No	ClinGen ExAC gnomAD
rs1471541465 CA344491076	79	K>R		No	ClinGen gnomAD
rs1572626398 CA344491016	82	P>R		No	ClinGen Ensembl
rs138817695 CA1364793	83	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1364794 rs138817695	83	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1338326 CA36566171 rs995859431	83	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs774368392 CA1364790	85	N>H		No	ClinGen ExAC gnomAD
TCGA novel	86	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344490945 rs1398249741	87	F>L		No	ClinGen TOPMed gnomAD
CA344490900 rs1358717797	89	V>E		No	ClinGen TOPMed
CA344490818 rs1401986782	94	L>P		No	ClinGen TOPMed
CA36566152 rs976794970	98	D>G		No	ClinGen TOPMed
CA1364788 CA1364787 rs371358524	99	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs769287956 CA1364786	100	G>R		No	ClinGen ExAC TOPMed gnomAD
rs376942711 CA1364785	101	V>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1329050310 CA344490701	101	V>I		No	ClinGen TOPMed gnomAD
rs1329624598 CA344490670	103	A>T		No	ClinGen gnomAD
rs150550509 COSM903028 CA1364783	105	G>R	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA344490629 rs1327644479	106	A>T		No	ClinGen gnomAD
CA1364782 rs138175929 COSM903027	106	A>V	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA1364779 rs753245238	107	G>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	108	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765483125 CA1364778	110	T>A		No	ClinGen ExAC gnomAD
CA1364777 rs755042951	110	T>I		No	ClinGen ExAC gnomAD
rs754128185 CA344490592	111	D>E		No	ClinGen ExAC gnomAD
rs200225589 CA36566063	112	R>Q		No	ClinGen 1000Genomes TOPMed gnomAD
rs768410930 CA1364775	112	R>W		No	ClinGen ExAC TOPMed gnomAD
rs774062671 TCGA novel CA1364773	113	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC gnomAD
CA1364774 rs761700601	113	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1364772 rs763935075	116	Q>R		No	ClinGen ExAC gnomAD
rs571196023 CA36566010	120	L>M		No	ClinGen Ensembl
TCGA novel	120	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1364769 rs368812381	123	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs758995799 CA1364768	124	S>N		No	ClinGen ExAC gnomAD
rs1305440183 CA344490511	125	E>K		No	ClinGen gnomAD
CA344490300 rs1486698912	126	Y>H		No	ClinGen gnomAD
rs749787467 CA1364740	127	E>K		No	ClinGen ExAC TOPMed gnomAD
CA1364739 rs780062992	128	P>L		No	ClinGen ExAC gnomAD
rs756152640 CA1364738	130	W>C		No	ClinGen ExAC gnomAD
rs1572625134 CA344490187	132	E>D		No	ClinGen Ensembl
rs1386407212 CA344490193	132	E>Q		No	ClinGen TOPMed
CA1364737 rs750622888	133	Q>*		No	ClinGen ExAC gnomAD
CA344490166 rs1181752667	135	M>I		No	ClinGen Ensembl
CA1364736 rs369159077	135	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs758215939 CA1364735	137	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1233750449 CA344490154	137	E>V		No	ClinGen gnomAD
CA344490135 rs1356846866	140	K>T		No	ClinGen gnomAD
CA344490124 rs1417730538	141	W>C		No	ClinGen gnomAD
rs1001678575 CA36565251	141	W>L		No	ClinGen TOPMed gnomAD
rs1295897477 CA344490130	141	W>R		No	ClinGen TOPMed gnomAD
CA344490110 rs1354749224	143	H>Q		No	ClinGen gnomAD
COSM212961 rs141485983 CA1364734	143	H>Y	breast [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA1364733 rs764992422	144	L>M		No	ClinGen ExAC gnomAD
rs1230124154 CA344490105	144	L>R		No	ClinGen TOPMed
CA344490108 rs764992422	144	L>V		No	ClinGen ExAC gnomAD
rs1403969048 CA344490104	145	P>T		No	ClinGen gnomAD
rs150066058 CA1364732	147	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1364731 rs753811648	149	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs765816162 CA1364730	149	Q>P		No	ClinGen ExAC gnomAD
CA36565164 rs916059713	155	S>G		No	ClinGen TOPMed gnomAD
CA1364727 rs767239321	158	K>R		No	ClinGen ExAC gnomAD
CA1364726 rs199994920	159	F>L		No	ClinGen ExAC TOPMed gnomAD
CA1364725 rs774906493	160	V>I		No	ClinGen ExAC gnomAD
rs578060627 CA1364724	161	T>N		No	ClinGen 1000Genomes ExAC gnomAD
rs1281930734 CA344489973	163	V>A		No	ClinGen gnomAD
CA1364722 rs776007536	163	V>I		No	ClinGen ExAC gnomAD
CA1364704 rs111888932	166	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA344489958 rs111888932	166	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1364703 rs549231837	167	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs776746733 CA1364702	169	R>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	171	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344489919 rs1171820744	172	V>L		No	ClinGen TOPMed gnomAD
rs144958422 CA1364700	173	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA36564420 rs912263913	173	P>S		No	ClinGen TOPMed
rs1558001980 CA344489900	175	V>A		No	ClinGen Ensembl
CA344489891 rs1359818361 CA344489892	176	H>Q		No	ClinGen TOPMed gnomAD
rs747239800 CA344489890	177	H>N		No	ClinGen ExAC gnomAD
rs747239800 CA1364697	177	H>Y		No	ClinGen ExAC gnomAD
CA1364696 rs777918268	178	S>P		No	ClinGen ExAC gnomAD
rs1486143138 CA344489861	181	T>I		No	ClinGen gnomAD
CA1364692 rs756128168	182	T>A		No	ClinGen ExAC gnomAD
rs767139267 CA1364690	185	T>I		No	ClinGen ExAC gnomAD
CA1364688 rs751278999	186	H>Q		No	ClinGen ExAC gnomAD
CA1364689 rs756767560	186	H>R		No	ClinGen ExAC gnomAD
CA1364687 rs763799731	187	R>C	Variant assessed as Somatic; 4.658e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs763799731 CA36564282	187	R>G		No	ClinGen ExAC TOPMed gnomAD
CA1364686 rs762478139	187	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA344489829 rs763799731	187	R>S		No	ClinGen ExAC TOPMed gnomAD
CA1364685 rs540532782	188	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA1364684 rs765056259 COSM1689746	189	R>*	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs760153308 CA1364683	189	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA344489814 rs1414261006	190	V>A		No	ClinGen gnomAD
rs1315049402 CA344489780	196	V>L		No	ClinGen gnomAD
CA1364681 rs371965045	198	G>D		No	ClinGen ESP ExAC gnomAD
rs1558001844 CA344489753	200	K>T		No	ClinGen Ensembl
CA1364679 rs773454788	201	P>S		No	ClinGen ExAC gnomAD
CA1364680 rs773454788	201	P>T		No	ClinGen ExAC gnomAD
CA1364678 rs533046547	202	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs748297804 CA36564228	207	S>P		No	ClinGen ExAC TOPMed gnomAD
rs748297804 CA1364677	207	S>T		No	ClinGen ExAC TOPMed gnomAD
CA36564226 COSM1500738 rs1001936972	209	T>A	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA344489679 rs1425677268	213	I>V		No	ClinGen gnomAD
rs1326234282 CA344489667	214	S>*		No	ClinGen TOPMed
rs962595967 CA36564214	215	A>S		No	ClinGen TOPMed gnomAD
rs1212608529 CA344489662	215	A>V		No	ClinGen gnomAD
rs1572623465 CA344489657	216	L>R		No	ClinGen Ensembl
rs371800032 CA36564205	218	G>V		No	ClinGen Ensembl
rs575369868 CA36564190	223	Q>H		No	ClinGen 1000Genomes ExAC gnomAD
CA344489608 rs748391555	224	T>K		No	ClinGen ExAC TOPMed gnomAD
CA1364673 rs748391555	224	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1572623428 CA344489611	224	T>P		No	ClinGen Ensembl
CA344489606 rs892091345	225	P>S		No	ClinGen TOPMed gnomAD
CA36564157 rs892091345	225	P>T		No	ClinGen TOPMed gnomAD
rs1233166727 COSM903025 CA344489598	226	S>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1572623372 CA344489582	228	N>T		No	ClinGen Ensembl
rs1483126597 CA344489575	229	H>D		No	ClinGen TOPMed
CA1364671 rs751151949	229	H>Q		No	ClinGen ExAC TOPMed
rs777121550 CA1364670	230	H>R		No	ClinGen ExAC gnomAD
rs1024264656 CA36564148	230	H>Y		No	ClinGen TOPMed
CA344489559 rs1396030280	231	T>I		No	ClinGen gnomAD
CA344489556 rs1297445395	232	R>K		No	ClinGen TOPMed gnomAD
CA344489540 rs368503889	234	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs375707563 CA1364666 CA344489533	235	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1000837926 CA344489520	237	R>I		No	ClinGen TOPMed gnomAD
CA36564141 rs1000837926	237	R>T		No	ClinGen TOPMed gnomAD
CA344489337 rs1203839656	238	A>P		No	ClinGen TOPMed gnomAD
CA344489338 rs1203839656	238	A>T		No	ClinGen TOPMed gnomAD
rs1261339339 CA344489315	241	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA344489273 rs1558000992	244	Q>H		No	ClinGen Ensembl
CA344489256 rs1288691232	245	S>F		No	ClinGen TOPMed
rs1241511089 CA344489247	246	G>E		No	ClinGen gnomAD
rs754241381 CA1364646	246	G>W		No	ClinGen ExAC
rs1558000959 CA344489200	249	G>D		No	ClinGen Ensembl
CA344489183 rs1371386849	250	Q>R		No	ClinGen TOPMed gnomAD
CA344489172 rs1325480523	251	G>R		No	ClinGen gnomAD
CA344489125 rs1380406873	253	H>R		No	ClinGen gnomAD
CA1364645 rs566552943	254	I>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA344489113 rs566552943	254	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs756673216 CA1364644	255	L>P		No	ClinGen ExAC
CA1364643 rs376892573	257	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA344489061 rs376892573	257	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1172562819 CA344489048	258	T>I		No	ClinGen gnomAD
rs1172562819 CA344489044	258	T>S		No	ClinGen gnomAD
rs1259949045 CA344489039	259	I>V		No	ClinGen TOPMed
rs866697158 CA36563391	260	L>M		No	ClinGen Ensembl
rs1454989144 CA344489014	260	L>R		No	ClinGen gnomAD
CA344489007 rs1248783128	261	G>S		No	ClinGen gnomAD
CA36563384 rs895473135	262	L>F		No	ClinGen TOPMed
CA1364640 rs200596517	265	L>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1218884961 CA344488969	266	A>T		No	ClinGen gnomAD
rs1015080050 CA36563377	267	L>F		No	ClinGen TOPMed gnomAD
rs1180200740 CA344488962	267	L>H		No	ClinGen TOPMed
TCGA novel	268	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1364639 rs764263343	269	G>V		No	ClinGen ExAC gnomAD
rs770585880 CA1364638	271	V>A		No	ClinGen ExAC TOPMed gnomAD
rs776621652 CA1364637	274	R>K		No	ClinGen ExAC
rs776621652 CA344488883	274	R>M		No	ClinGen ExAC
rs1276370549 CA344488862	275	A>D		No	ClinGen gnomAD
CA344488869 rs1345479032	275	A>T		No	ClinGen gnomAD
TCGA novel	277	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344488837 rs1225201506	277	E>Q		No	ClinGen gnomAD
CA1364636 rs770843304	278	R>S		No	ClinGen ExAC TOPMed gnomAD
CA344488697 rs1295523063	281	A>D		No	ClinGen TOPMed
rs1338436984 CA344488617	285	R>P		No	ClinGen gnomAD
CA344488581 rs1450377521	287	R>G		No	ClinGen TOPMed
rs1278764915 CA344488559	288	R>*		No	ClinGen TOPMed gnomAD
rs1278764915 CA344488561	288	R>G		No	ClinGen TOPMed gnomAD
rs1220352913 CA344488552	288	R>L		No	ClinGen TOPMed gnomAD
rs1353050525 CA344488515	290	A>D		No	ClinGen gnomAD
rs1187597174 CA344488522	290	A>T		No	ClinGen TOPMed
CA344488466 rs1387907494	292	R>S		No	ClinGen TOPMed
CA344488418 rs887911195	295	A>S		No	ClinGen TOPMed gnomAD
rs887911195 CA36563059	295	A>T		No	ClinGen TOPMed gnomAD
rs1403472231 CA344488397	296	L>P		No	ClinGen TOPMed
CA36563052 rs867145899	297	E>G		No	ClinGen TOPMed gnomAD
rs1306588532 CA344488374	299	S>T		No	ClinGen gnomAD
CA344488372 rs1273383310	299	S>Y		No	ClinGen gnomAD
CA344488361 rs1572620676	300	Q>H		No	ClinGen Ensembl
CA1364622 rs559575559	301	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1364623 rs559575559	301	R>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1364621 rs763329858	303	R>G		No	ClinGen ExAC gnomAD
CA344488340 rs1417295011	303	R>H		No	ClinGen gnomAD
CA344488334 rs1342784261	304	G>R		No	ClinGen gnomAD
rs546416340 CA344488323	305	S>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1364620 rs546416340	305	S>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA36563014 rs1056457856	306	P>L		No	ClinGen gnomAD
CA1364619 rs192734594	307	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs760340568 CA1364618	308	P>T		No	ClinGen ExAC TOPMed gnomAD
CA36562996 rs1043626156	309	R>H		No	ClinGen Ensembl
rs773235214 CA1364617	311	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs773235214 CA344488273	311	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA344488257 rs1200509662	313	N>S		No	ClinGen gnomAD
rs1039020260 CA36562979	314	I>L		No	ClinGen TOPMed
CA36562972 rs563855490	317	A>T		No	ClinGen 1000Genomes
CA36562966 rs749750564	318	C>F		No	ClinGen Ensembl
rs771946459 CA1364615	318	C>R		No	ClinGen ExAC gnomAD
rs946541423 CA36562955	320	R>L		No	ClinGen TOPMed
rs1380636734 CA344488191	321	R>P		No	ClinGen gnomAD
CA344488195 rs1355387443	321	R>S		No	ClinGen TOPMed gnomAD
CA344488186 rs1172946534	322	A>P		No	ClinGen TOPMed gnomAD
CA344488185 rs1172946534	322	A>T		No	ClinGen TOPMed gnomAD
CA344488176 rs1277415546	323	R>G		No	ClinGen TOPMed gnomAD
CA344488172 rs1572620420	323	R>L		No	ClinGen Ensembl
CA344488177 rs1277415546	323	R>S		No	ClinGen TOPMed gnomAD
rs779209742 CA1364614	324	G>A		No	ClinGen ExAC gnomAD
rs779209742 CA344488164	324	G>V		No	ClinGen ExAC gnomAD
rs773792868 CA344488156	325	A>G		No	ClinGen ExAC TOPMed gnomAD
CA1364613 rs773792868	325	A>V		No	ClinGen ExAC TOPMed gnomAD
CA36562895 rs992570170	326	D>E		No	ClinGen TOPMed
rs544145639 CA36562910	326	D>G		No	ClinGen 1000Genomes TOPMed
CA36562917 rs918083375	326	D>N		No	ClinGen TOPMed gnomAD
CA36562686 rs929539458	329	G>A		No	ClinGen TOPMed gnomAD
CA36562652 rs922378937	331	G>E		No	ClinGen Ensembl
rs1271654408 CA344488102	331	G>W		No	ClinGen Ensembl
CA344488094 rs1329001271	332	E>*		No	ClinGen TOPMed
rs1303532689 CA344488082	333	A>V		No	ClinGen TOPMed
rs377292566 CA36562647	335	V>I		No	ClinGen TOPMed
CA344488040 rs1420617186	336	P>H		No	ClinGen gnomAD
rs1313900016 CA344488025	337	G>D		No	ClinGen TOPMed gnomAD
rs372229079 CA1364602	337	G>S		No	ClinGen 1000Genomes ExAC gnomAD
CA344488000 rs1453566159	338	P>L		No	ClinGen TOPMed
rs1572619894 CA344488012	338	P>S		No	ClinGen Ensembl
CA344487900 rs765519847	343	P>A		No	ClinGen ExAC TOPMed gnomAD
CA1364601 rs765519847	343	P>S		No	ClinGen ExAC TOPMed gnomAD
CA344487827 rs1393263270	346	P>Q		No	ClinGen TOPMed
rs985030613 CA36562606	348	Q>H		No	ClinGen TOPMed gnomAD
rs1572619821 CA344487800	348	Q>K		No	ClinGen Ensembl
rs774948123 CA1364593	349	V>L		No	ClinGen ExAC TOPMed gnomAD
CA344487178 rs1362466905	351	E>G		No	ClinGen gnomAD
rs1418063460 CA344487168	353	P>S		No	ClinGen TOPMed gnomAD
CA344487149 rs1401813006	355	L>P		No	ClinGen TOPMed
rs1434288566 CA344487145	356	H>Y		No	ClinGen gnomAD
CA1364591 rs41304091	357	A>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs41304091 CA1364590	357	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs771257745 CA1364589	358	P>L		No	ClinGen ExAC TOPMed gnomAD
CA344487132 rs771257745	358	P>R		No	ClinGen ExAC TOPMed gnomAD
CA344487133 rs1176517937	358	P>S		No	ClinGen gnomAD
CA344487110 rs1417312230	362	T>A		No	ClinGen gnomAD
rs1477878353 CA344487090	364	C>W		No	ClinGen gnomAD
rs200690250 CA1364587	365	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA344487078 rs1208336957	366	Y>C		No	ClinGen TOPMed gnomAD
rs758585451 CA344487074	367	V>L		No	ClinGen ExAC gnomAD
rs758585451 CA1364586	367	V>M		No	ClinGen ExAC gnomAD
rs1572612816 CA344487052	370	Y>S		No	ClinGen Ensembl
rs1572612801 CA344487044	371	H>P		No	ClinGen Ensembl
rs1572612771 CA344487027	373	P>R		No	ClinGen Ensembl
rs200837472 CA1364582	375	A>T		No	ClinGen ExAC TOPMed gnomAD
CA344487015 rs1209825651	375	A>V		No	ClinGen TOPMed
rs138108842 CA1364580	376	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs767222143 CA1364581	376	M>T		No	ClinGen ExAC gnomAD
CA344487013 rs1288276186	376	M>V		No	ClinGen TOPMed
rs751526857 CA1364579	377	M>I		No	ClinGen ExAC gnomAD
rs1414466795 CA344486999	378	E>K		No	ClinGen gnomAD
rs1304747353 CA344486971	381	D>G		No	ClinGen gnomAD
rs1199975719 CA344486954	383	D>E		No	ClinGen TOPMed
CA1364577 rs762854507	384	D>N		No	ClinGen ExAC gnomAD
CA1364576 rs775039633	386	I>L		No	ClinGen ExAC gnomAD
rs775039633 CA344486938	386	I>V		No	ClinGen ExAC gnomAD
CA1364574 rs769337842	387	N>S		No	ClinGen ExAC TOPMed gnomAD
rs867831977 CA36559493	387	N>Y		No	ClinGen Ensembl
rs1009267266 CA36559477	389	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs142847006 CA1364573	389	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1364572 rs776285839	390	A>S		No	ClinGen ExAC gnomAD
CA1364571 rs771220479	391	A>R		No	ClinGen ExAC gnomAD
TCGA novel	391	A>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with O60667

2 regional properties for O60667

Type	Name	Position	InterPro Accession
domain	Immunoglobulin subtype	22 - 123	IPR003599
domain	Immunoglobulin V-set domain	23 - 123	IPR013106

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Single-pass membrane protein Early endosome membrane ; Single-pass membrane protein Golgi apparatus, trans-Golgi network membrane ; Single-pass membrane protein Lysosome membrane ; Single-pass membrane protein	Continuously recycles between cytoplasmic pool and the plasma membrane to bind as much IgM as possible
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name	Definition
transmembrane signaling receptor activity	Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.

3 GO annotations of biological process

Name	Definition
cellular defense response	A defense response that is mediated by cells.
immune system process	Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MDFWLWPLYF	LPVSGALRIL	PEVKVEGELG	GSVTIKCPLP	EMHVRIYLCR	EMAGSGTCGT
70	80	90	100	110	120
VVSTTNFIKA	EYKGRVTLKQ	YPRKNLFLVE	VTQLTESDSG	VYACGAGMNT	DRGKTQKVTL
130	140	150	160	170	180
NVHSEYEPSW	EEQPMPETPK	WFHLPYLFQM	PAYASSSKFV	TRVTTPAQRG	KVPPVHHSSP
190	200	210	220	230	240
TTQITHRPRV	SRASSVAGDK	PRTFLPSTTA	SKISALEGLL	KPQTPSYNHH	TRLHRQRALD
250	260	270	280	290	300
YGSQSGREGQ	GFHILIPTIL	GLFLLALLGL	VVKRAVERRK	ALSRRARRLA	VRMRALESSQ
310	320	330	340	350	360
RPRGSPRPRS	QNNIYSACPR	RARGADAAGT	GEAPVPGPGA	PLPPAPLQVS	ESPWLHAPSL
370	380
KTSCEYVSLY	HQPAAMMEDS	DSDDYINVPA