O60179

PR
Gene name
utp10 (SPBC23E6.04c)
Protein name
U3 small nucleolar RNA-associated protein 10
Names
U3 snoRNA-associated protein 10, U3 protein 10 required for transcription
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC23E6.04c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

380-476 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O60179

Entry ID Method Resolution Chain Position Source
AF-O60179-F1 Predicted AlphaFoldDB

No variants for O60179

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O60179

No associated diseases with O60179

3 regional properties for O60179

Type Name Position InterPro Accession
domain BP28, C-terminal domain 1377 - 1519 IPR012954
repeat HEAT, type 2 1608 - 1646 IPR021133
domain U3 small nucleolar RNA-associated protein 10, N-terminal 243 - 346 IPR022125

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
90S preribosome A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
preribosome, small subunit precursor A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.
small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
t-UTP complex A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p.

1 GO annotations of molecular function

Name Definition
snoRNA binding Binding to a small nucleolar RNA.

2 GO annotations of biological process

Name Definition
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
positive regulation of transcription by RNA polymerase I Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASSLQKQLK NIQSNNVLKI NKIRRAPSLL YDPKVAADMD LEEIYVTAVS GFHELAVHEP
70 80 90 100 110 120
RLLYFEKTLL GEQSVQVDRV LLNRTENEKI DLECVQILRL LAPFFTEKNA LKVLEWLIRR
130 140 150 160 170 180
FSIHEYVSDE FILSFLPFHD HPFFARILGC SKPKSRPLLF LENAIKMPVT LSRADIVHAL
190 200 210 220 230 240
SRDKEFFAMF AQFVQNTAES HNMYPELARF WAGTMMEVLV AWHSSNEDPN VLLDRFFLRV
250 260 270 280 290 300
SYAVSYVSSI DFQIAGFMLL SSIAASLPLS PSIIPPLVSA ITDRLSFDNI KPALICVGHL
310 320 330 340 350 360
LQFCSSFEFD HEQLEKLESF GASSLLIELS QEHRLDEFFV SYWVSLIKSR KQKDKKRLIS
370 380 390 400 410 420
LLDTSISQIR VTHEQAKFLL SVIPVNQDFK ALQSYRRILD SVIQPERKEG KLDNLINTLQ
430 440 450 460 470 480
DKKKSSTFSK KDREVLLKKI SEIDSQTSFE QCLAYADSAA DLDSSVFISL LSKFGDKIPF
490 500 510 520 530 540
LLFCIANGSE RIIILSLIEL RKTIEENKDV DYQIILPVVL YSLQSKDTEV RSRALNLILT
550 560 570 580 590 600
FLELRNENLE FSIIYGMDDN DNKNLRWLSP VETKYYCSDL LLDRSSEIGL DGTYLFSYIP
610 620 630 640 650 660
ERLFTEKKPK NASKEIAVTS FLSSHAACSK LSNVRVLLLE ILTRVHGKVE DAKMQILLPR
670 680 690 700 710 720
LEQLSEFNSE KFKTVSKREV EALVNCFNHT SFTSLLSFLS SNIVLSQAIC RRIVEIQSHL
730 740 750 760 770 780
KDPQRLEFVK AVISQDEQPH YYVDVLDSIK IPDTVFKKLI GSVRLVKEKN PAIAKRKRID
790 800 810 820 830 840
SHIFDGDVQR LTRILELLET KNAASYPKLA SPLFEVLNSV IALKEDIVSS NYLLQLLLGL
850 860 870 880 890 900
LYEMIGASPI TELSPSIRID TLVGCIRSTN NPQIQNKALL LVSALANAAP EAVLHGVMPI
910 920 930 940 950 960
FTFMGSTVLS RDDAFSIHVI EQTVKTVISA LIRLGKDFDS SLLVSCFVNA FPHIPQHRRL
970 980 990 1000 1010 1020
RLYRLVLQTI GSNRFLSVVL IQFAEKMLLA KSTNVVAIHD FCLTLVQSFS VADRIGSINQ
1030 1040 1050 1060 1070 1080
CSRFCLKSLE EQSNSDSNGK AVSLIKLDEL PMDVDLATLG SLRVKVLELI SLVSKAKNFA
1090 1100 1110 1120 1130 1140
FDLAKIMENS VDSFVEIQAG LFESIKLLIT LSQQSSNEME LGHVYVALRS VIHLLPNELF
1150 1160 1170 1180 1190 1200
CTVLGKLLHD ERALLRRKAL SIVQQRVQQG SKVSALTALI PDVTYNISNY SDEETTQLAM
1210 1220 1230 1240 1250 1260
DCLAVMAKRF SASPELFISP IEVVSGPYGL KNSARDVQVS AIVCITVLTN TLAARILPYL
1270 1280 1290 1300 1310 1320
ADIVNYSLSI LDDARKDPEG DLLELACFSM MIDFFKVLPE FSSSYVEPTI KCALASDRAF
1330 1340 1350 1360 1370 1380
EHDAIGELLF ETIANFIPTR LLMKSIFAAW PECARLGSTA ALRLLELIEL ALQNSSRSAI
1390 1400 1410 1420 1430 1440
GTVYKSIFKF FLDSFDSRRS LLFAEDVDNV ETQAVNVFLK FVMKLSDTTF RPLFLHLHSW
1450 1460 1470 1480 1490 1500
ALEDLYETDP SGIVSRQTFF YNFLTIFLDT LKSIVTNYYA YVLDDTIELL SSKDTNSEVR
1510 1520 1530 1540 1550 1560
HLVNSSLVSA FENDTEEFWM VPARFGKISP VLIEQIQYAP LLDDKVLVKA IVELASVASS
1570 1580 1590 1600 1610 1620
SDNFRSMNTQ LLQYLRSSNI NARLLAIQIQ TQLYGRLGEN WISTLPQSVP FIAELMEDDD
1630 1640
DQVETATAEL VRIIDDRLGE NESLQDYLT