O60145

PR
Gene name
ppk23 (SPBC18H10.15)
Protein name
Serine/threonine-protein kinase ppk23
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC18H10.15
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-93 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

215-238 (Activation loop from InterPro)

Target domain

74-359 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for O60145

Entry ID Method Resolution Chain Position Source
AF-O60145-F1 Predicted AlphaFoldDB

No variants for O60145

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O60145

No associated diseases with O60145

3 regional properties for O60145

Type Name Position InterPro Accession
domain Protein kinase domain 74 - 359 IPR000719
active_site Serine/threonine-protein kinase, active site 194 - 206 IPR008271
domain Cyclin-dependent kinase 11/PITSLRE, catalytic domain 68 - 359 IPR045267

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

4 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of mitotic cell cycle Any process that modulates the rate or extent of progress through the mitotic cell cycle.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
signaling The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGSKWETEE TNQFAIENQK LEEEWRKKRR LEKKRKRKIL EEEEKAEERN IDACRLYLMG
70 80 90 100 110 120
NTPELKSCNS IDDYEILEKI EEGSYGIVYR GLDKSTNTLV ALKKIKFDPN GIGFPITSLR
130 140 150 160 170 180
EIESLSSIRH DNIVELEKVV VGKDLKDVYL VMEFMEHDLK TLLDNMPEDF LQSEVKTLML
190 200 210 220 230 240
QLLAATAFMH HHWYLHRDLK PSNLLMNNTG EIKLADFGLA RPVSEPKSSL TRLVVTLWYR
250 260 270 280 290 300
APELLLGAPS YGKEIDMWSI GCIFAEMITR TPLFSGKSEL DQLYKIFNLL GYPTREEWPQ
310 320 330 340 350 360
YFLLPYANKI KHPTVPTHSK IRTSIPNLTG NAYDLLNRLL SLNPAKRISA KEALEHPYFY
370 380 390
ESPRPKDPKF FPTFPSKAKG ESKEKNVFQS FRSASPKK