O60126
Gene name |
top3 (SPBC16G5.12c) |
Protein name |
DNA topoisomerase 3 |
Names |
DNA topoisomerase III |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPBC16G5.12c |
EC number |
5.6.2.1: Enzymes altering nucleic acid conformation |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O60126
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O60126-F1 | Predicted | AlphaFoldDB |
No variants for O60126
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O60126 | |||||
No associated diseases with O60126
10 regional properties for O60126
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA topoisomerase, type IA, domain 2 | 107 - 195 | IPR003601 |
| domain | DNA topoisomerase, type IA, DNA-binding domain | 249 - 519 | IPR003602 |
| domain | TOPRIM domain | 1 - 116 | IPR006171 |
| domain | DNA topoisomerase, type IA, central | 75 - 88 | IPR013497-1 |
| domain | DNA topoisomerase, type IA, central | 131 - 567 | IPR013497-2 |
| domain | DNA topoisomerase, type IA, zn finger | 599 - 633 | IPR013498 |
| active_site | DNA topoisomerase, type IA, active site | 286 - 308 | IPR023406 |
| repeat | Topoisomerase C-terminal repeat | 661 - 718 | IPR025589-1 |
| repeat | Topoisomerase C-terminal repeat | 720 - 769 | IPR025589-2 |
| domain | DNA topoisomerase 1, TOPRIM domain | 1 - 128 | IPR034149 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.6.2.1 | Enzymes altering nucleic acid conformation |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| RecQ family helicase-topoisomerase III complex | A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human. |
| site of double-strand break | A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA topoisomerase activity | Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. |
| DNA topoisomerase type I (single strand cut, ATP-independent) activity | Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA topological change | The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. |
| maintenance of rDNA | Any process involved in sustaining the fidelity and copy number of rDNA repeats. |
| mitotic DNA replication | Any nuclear DNA replication that is involved in a mitotic cell cycle. |
| postreplication repair | The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication. |
| resolution of meiotic recombination intermediates | The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRVLCVAEKN | SIAKSVASIL | GGGHVRRRDT | RSKYVKNYDF | SFNFGGNVGS | SDVTMTSVSG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HLTEASFPSE | YSSWSSVPQD | VLFDAQIITS | VSKNAEVLAD | NIKKEARNAQ | YLYIWTDCDR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EGEHIGVEIS | NVARASNPSI | QVIRADFNNL | ERSHIISAAK | RPRDVSKNAA | DAVDARIELD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FRLGAIFTRL | QTIQLQKSFD | ILQNKIISYG | PCQFPTLGFV | VDRWQRVEDF | VPETYWHLRF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VDKRQGKTIQ | FNWERAKVFD | RLTTMIILEN | CLECKTAKVV | NITQKPKTKY | KPLPLSTVEL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TKLGPKHLRI | SAKKTLELAE | NLYTNGFVSY | PRTETDQFDS | SMNLHAIIQK | LTGAQEWDSY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AEGLLAGDYR | PPRKGKHNDR | AHPPIHPVQM | VHRSALPSQD | HWKVYELITR | RFLACCSDNA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KGAETLVQVK | MEEELFSKKG | LLVTEKNYLE | VYPYEKWESS | DQLPEYRLHE | EFQPHILDMM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DSSTSSPSYI | TEPELIALMD | ANGIGTDATM | AEHIEKVQER | EYVIKRKKRG | QGVTEFVPSS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LGVALAKGYD | EIGLEWSLTK | PFLRKEMEVQ | LKNIENGQLN | RNVLVHMILT | QFRDVFHLTK |
| 610 | 620 | ||||
| QRFDCLKNSC | RVYLMSHNEP | QT |