O60105

PR
Gene name
ade8 (SPBC14F5.09c)
Protein name
Adenylosuccinate lyase
Names
ASL, Adenylosuccinase, ASase
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC14F5.09c
EC number
4.3.2.2: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

422-482 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O60105

Entry ID Method Resolution Chain Position Source
AF-O60105-F1 Predicted AlphaFoldDB

No variants for O60105

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O60105

No associated diseases with O60105

3 regional properties for O60105

Type Name Position InterPro Accession
domain Adenylosuccinate lyase C-terminal 374 - 458 IPR019468
conserved_site Fumarate lyase, conserved site 285 - 294 IPR020557
domain Fumarate lyase, N-terminal 38 - 308 IPR022761

Functions

Description
EC Number 4.3.2.2 Lyases acting on amides, amidines, etc
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.

3 GO annotations of biological process

Name Definition
'de novo' AMP biosynthetic process The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP).
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
fumarate metabolic process The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEDYGSYSTP LTARYASAEM SHLFSREMRI NTWRQLWLNL AIAEKQLGLT QITDEAIEQL
70 80 90 100 110 120
KAHVKITAPE FEIAAKEEKR QRHDVMAHIY TYGLAAPAAS GIIHLGATSC FVTDNADLIF
130 140 150 160 170 180
LRSAMDLLIP KLVNVINRLS QWSLRYKDIP TLGFTHYQPA QLTTVGKRAT LWIQELLWDL
190 200 210 220 230 240
RNFVRARNDI GFRGVKGTTG TQASFLALFE GDHAKVEELD KLVAKLSGFD NVYPVTGQTY
250 260 270 280 290 300
DRKIDIDVLQ PLASFGATAH KIATDIRLLA NLKEVEEPFE AGQIGSSAMA YKRNPMRCER
310 320 330 340 350 360
ICSQARYIMN LIPNALNTAS VQWFERTLDD SSNRRSLLPE AFLFTDSVLK ILLNVISGMV
370 380 390 400 410 420
IYPKVIQKHI RAELPFMATE NIIMAMTKHG ASRHECHEQI RVLSHQAGRV VKEEGGDNDL
430 440 450 460 470 480
IERIKNTPYF APIYDELDSL LDASTFVGRA PEQTESFVNK DVSQALAPFK SMITEEKVDL
AV