O60084

PR
Gene name
tim44 (SPBC14C8.02)
Protein name
Mitochondrial import inner membrane translocase subunit tim44
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC14C8.02
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-272 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O60084

Entry ID Method Resolution Chain Position Source
AF-O60084-F1 Predicted AlphaFoldDB

No variants for O60084

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O60084

No associated diseases with O60084

2 regional properties for O60084

Type Name Position InterPro Accession
domain Ubiquitin-conjugating enzyme E2 8 - 174 IPR000608
active_site Ubiquitin-conjugating enzyme, active site 82 - 97 IPR023313

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
PAM complex, Tim23 associated import motor Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the TIM23 mitochondrial import inner membrane translocase complex (GO:0005744); ATPase motor activity to drive import of proteins into the mitochondrial matrix.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
chaperone binding Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.

1 GO annotations of biological process

Name Definition
protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFLSRKITKN ARTIVQCQRF FQTSIFSQNA APQSPIKVFM DTFRAELKKS QELQDSVKAL
70 80 90 100 110 120
QDSSGSLSES DTFKKARDAY EKARSGTTAA SSFTGKTVGK AGAKIGSYAQ KAWESAPVQL
130 140 150 160 170 180
SKKVISSTAN TVATGVDTAT KPVRETAFYK TIKQTMSDGS TSSRYGFYAD KEQRKKLREE
190 200 210 220 230 240
FERRNRMFAS SARIQPNEDV QSVVVHSNPS WKNKVEQIKN ESRLVRKIQE LKKSYQESEH
250 260 270 280 290 300
PIVSSIRDMA DSISGVWSRM FSETEASQVM RRFKEIDPSF NTEHFLQYLR EYIVPEVTEA
310 320 330 340 350 360
YVKGDKEVLK TWLSEAPFSV YETTTKEYAK HGVVSVGKIL DIRGVDIMSQ RLLQPNDIPV
370 380 390 400 410 420
FIVTFRTQEV HMFKDASSGE LVAGKDDRIQ QCTYASVFTR VEDELDNPET RGWRIVDFAR
ARAVDYF