O60059

PR
Gene name
SPBC56F2.08c
Protein name
Pumilio domain-containing protein C56F2.08c
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC56F2.08c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

43-192 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for O60059

Entry ID Method Resolution Chain Position Source
6NWW X-ray 206 A A/B/C/D 1-79 PDB
6NX5 X-ray 155 A A/B/C/D 1-79 PDB
6NY5 X-ray 300 A A/B 109-485 PDB
AF-O60059-F1 Predicted AlphaFoldDB

No variants for O60059

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O60059

No associated diseases with O60059

No regional properties for O60059

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O60059

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.

2 GO annotations of molecular function

Name Definition
mRNA 3'-UTR AU-rich region binding Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

1 GO annotations of biological process

Name Definition
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLYVSNLPVG TSSSAIHALF SAYGNVKDIW MLSPDNSAIV SYESLSSAIV ARDALHNRPV
70 80 90 100 110 120
FENHGPVQVM LAKPSSNYEP GNITAAVSPP ASTSSKDGVV CSPTSTGASQ LLKSRVDILE
130 140 150 160 170 180
VARQFEMRIN LDIVDSMIAS AIENNKVATE ILPPVETLRS RQFEASKLRE IRKNIDSGFY
190 200 210 220 230 240
TQEEIEVIAR SMLDDVAELS SDYLGNTVVQ KFFEYCSDPI KEAMLERIAP YLAAIGIHKN
250 260 270 280 290 300
GTWAAQKIID VASTEKQMDL IVKHLRPYTA LLYFDQFGNY VAQCCLRFKY PKNTFLFEVM
310 320 330 340 350 360
ARHCCEIGQS RFGARAIRAC LENENATFEQ QALVVASIII NSHLLATNSN GMLLLTWLLD
370 380 390 400 410 420
NSFFRNRHRL LAIHLATHLH TTCTHKLAST LIFKLINNKQ EPESRNLLLK NLFFSEKDNV
430 440 450 460 470 480
LTYILQDQAV GPSFIHKVIT YPSIGREFLA QFHLVIKRVL INIHAQPNAV YCRLMEEVGM
490 500 510 520 530 540
TSKSISPSLS GISAPSASVD SSASRLARDF GSLSLSSNSL LGSLGGLEST PAYPSYPSHI
550 560 570 580 590 600
PLGTASLPLK GNLYQISRSD DIKSGAPVLD TSSLVNPTLA KSASLNNSSL LNPSSSLLRR
610 620 630 640 650 660
EVPAGKLTMP AYPYTTQLMN HTAGADYGLP RLSSKLPQVF PGNYPRLQQS LFPRQGELRF
N