O59853

PR
Gene name
HOG2
Protein name
Mitogen-activated protein kinase HOG2
Names
MAP kinase HOG2, ZrHOG2
Species
Zygosaccharomyces rouxii (Candida mogii)
KEGG Pathway
EC number
2.7.11.24: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

281-420 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

161-181 (Activation loop from InterPro)

Target domain

23-302 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for O59853

Entry ID Method Resolution Chain Position Source
AF-O59853-F1 Predicted AlphaFoldDB

No variants for O59853

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O59853

No associated diseases with O59853

4 regional properties for O59853

Type Name Position InterPro Accession
domain Protein kinase domain 23 - 305 IPR000719
conserved_site Mitogen-activated protein (MAP) kinase, conserved site 58 - 156 IPR003527
active_site Serine/threonine-protein kinase, active site 140 - 152 IPR008271
binding_site Protein kinase, ATP binding site 29 - 53 IPR017441

Functions

Description
EC Number 2.7.11.24 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase activity Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

2 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.
stress-activated MAPK cascade The series of molecular signals in which a stress-activated MAP kinase cascade relays a signal; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATHEEFIRT QVFGTVFEIT NRYTDLNPVG MGAFGLVCSA TDTLVGQPVA IKKIMKPFST
70 80 90 100 110 120
AVLAKRTYRE LKLLKHLRHE NLICLQDIFL SPLEDIYFVT ELQGTDLHRL LQTRPLEKQF
130 140 150 160 170 180
VQYFLYQILR GLKYVHSAGV IHRDLKPSNI LINENCDLKI CDFGLARIQD PQMTGYVSTR
190 200 210 220 230 240
YYRAPEIMLT WQKYDVEVDI WSAGCIFSEM IEGKPLFPGK DHVHQFSIIT DLLGSPPRDV
250 260 270 280 290 300
INTICSENTL KFVTSLPHRD PVPFQERFKT VEPDAVDLLR RMLVFVPKKR ITAADALVHP
310 320 330 340 350 360
YLAPYHDPTD EPTAEAQFDW DFNDADLPVD TWRVMMYSEI LDFHKIGGGD GQIDTNAAFD
370 380 390 400 410
DQVAAAHAAA MAQHHHQTQQ QSSGKHTNPT TSSSAATITV TVPIAITMPS LIMVIKRFTT