O59816

PR
Gene name
lat1 (SPCC794.07)
Protein name
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Names
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, Pyruvate dehydrogenase complex component E2, PDC-E2, PDCE2
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC794.07
EC number
2.3.1.12: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-84 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O59816

Entry ID Method Resolution Chain Position Source
AF-O59816-F1 Predicted AlphaFoldDB

No variants for O59816

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O59816

No associated diseases with O59816

4 regional properties for O59816

Type Name Position InterPro Accession
domain Biotin/lipoyl attachment 53 - 129 IPR000089
domain 2-oxoacid dehydrogenase acyltransferase, catalytic domain 254 - 483 IPR001078
binding_site 2-oxo acid dehydrogenase, lipoyl-binding site 78 - 107 IPR003016
domain Peripheral subunit-binding domain 186 - 224 IPR004167

Functions

Description
EC Number 2.3.1.12 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
dihydrolipoyllysine-residue acetyltransferase activity Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide.

1 GO annotations of biological process

Name Definition
acetyl-CoA biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLSANMLRRM HHGVAVTRML LVSNGKVQVK KSALYPVMAK LARTYATKNY PAHTVINMPA
70 80 90 100 110 120
LSPTMTTGNI GAFQKKIGDK IEPGDVLCEI ETDKAQIDFE QQDEGYLAKI LIETGTKDVP
130 140 150 160 170 180
VGKPLAVTVE NEGDVAAMAD FTIEDSSAKE PSAKSGEEKS APSSEKQSKE TSSPSNVSGE
190 200 210 220 230 240
ERGDRVFASP LARKLAEEKD LDLSQIRGSG PNGRIIKVDI ENFKPVVAPK PSNEAAAKAT
250 260 270 280 290 300
TPAASAADAA APGDYEDLPL SNMRKIIASR LAESKNMNPH YYVTVSVNME KIIRLRAALN
310 320 330 340 350 360
AMADGRYKLS VNDLVIKATT AALRQVPEVN AAWMGDFIRQ YKNVDISMAV ATPSGLITPV
370 380 390 400 410 420
IRNTHALGLA EISTLAKDYG QRARNNKLKP EEYQGGTFTI SNLGMFPVDQ FTAIINPPQA
430 440 450 460 470 480
CILAVGTTVD TVVPDSTSEK GFKVAPIMKC TLSSDHRVVD GAMAARFTTA LKKILENPLE
IML