O59801

PR
Gene name
SPCC550.03c
Protein name
Putative ATP-dependent RNA helicase C550.03c
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC550.03c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

148-237 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O59801

Entry ID Method Resolution Chain Position Source
AF-O59801-F1 Predicted AlphaFoldDB

No variants for O59801

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O59801

No associated diseases with O59801

6 regional properties for O59801

Type Name Position InterPro Accession
domain Helicase, C-terminal 545 - 736 IPR001650
domain DEAD/DEAH box helicase domain 284 - 430 IPR011545
domain ATP-dependent RNA helicase Ski2/MTR4, C-terminal 1034 - 1213 IPR012961
domain Helicase superfamily 1/2, ATP-binding domain 277 - 460 IPR014001
domain rRNA-processing arch domain 747 - 1011 IPR025696
domain Ski2, N-terminal domain 60 - 185 IPR040801

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
Ski complex A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

4 GO annotations of biological process

Name Definition
endoplasmic reticulum unfolded protein response The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.
nuclear-transcribed mRNA catabolic process, non-stop decay The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon.
RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSKLVDAIN EVAVSNKDKI ELDGIKDDSF DGHLSITEAT YDVDTFLKPS PALSKDWIRK
70 80 90 100 110 120
LQKKWDREIT YKGLYEYPET LARTQIRFQR HGLEGKIMGY KEVPELIEDL NSKNSSSFLR
130 140 150 160 170 180
KPSSKNEFVR GSTSNIPFLA DDSDVDAIAG EPSVKMALYG EDGLLQVPPG FSRGLSMTAT
190 200 210 220 230 240
STTDNLNDEF DPEKWDTKKV KSSNRNFVTI HELNEHLKNV NSKHSEIDDL LPDKRSIVSL
250 260 270 280 290 300
PPSTLNLHKQ PDYAHVVDSS APIENFQQLV PEMALDFPFE LDNFQKEAIY HLEMGDSVFV
310 320 330 340 350 360
AAHTSAGKTV VAEYAIALAQ KHMTKAIYTS PIKALSNQKF RDFKHKFEDV GILTGDVQVN
370 380 390 400 410 420
PEGSCLLMTT EILRSMLYRG ADLIRDVEFV IFDEVHYVND LERGVVWEEV IIMLPPHVTL
430 440 450 460 470 480
ILLSATVPNT KEFASWVGRT KKKNIYVIST LKRPVPLEHY LWVKQNMFKI VDQHGRFLMD
490 500 510 520 530 540
GYKSANDALK KPDKPVIAKD NKNSARGRGA ARGRGVQTNM MRGRGSAKSV ERRDANTWVH
550 560 570 580 590 600
LIGHLHKQNL LPVIVFVFSK KRCEEYVDTL TNRDLNNHQE KSEVHVVIEK AVARLKKEDR
610 620 630 640 650 660
LLPQIGRMRE MLSRGLAVHH GGLLPIIKEI VEILFQRGLV KVLFATETFA MGVNMPAKSV
670 680 690 700 710 720
VFSGTQKHDG RNFRDLLPGE YTQCSGRAGR RGLDVTGTVI ILSRSELPDT ASLRHMIMGP
730 740 750 760 770 780
SSKLISQFRL TYNMILNLLR VETLRIEDMI KRSFSENVNQ TLVPQHEEKI KSFEEKLSAL
790 800 810 820 830 840
KKEMSDVDLK EIKSCLLSSE SFKEYTKKMH FRAITTANGK RIFKDGRVIV FQQLDFTRTV
850 860 870 880 890 900
GVLLGTSIRT NASDCTLEVA YLNPQNNLKR PSDLLAFADA FNDVYDNAIF DESNQFKYGL
910 920 930 940 950 960
INLSGIERVC NTILRIDSGG IRDRRGGAFR KLSEQFASIK KFSDLLFEEV NWSKVRDFEF
970 980 990 1000 1010 1020
CEAFEKRNFL QNKLSGNPII STPNFLTHFA LAYQEYELES NIDNLSSYIS DQNLELLPDY
1030 1040 1050 1060 1070 1080
EQRIKVLQEL GYIDAERTVL LKGRVACEIN STSELVLTEL ILENSLADFS CEETIALLSA
1090 1100 1110 1120 1130 1140
FVFDEKTEVE PTISPHLQKG KEMILSVAEK VNQIQEHYQV LYFNEGNDFE SQPRFGLMEV
1150 1160 1170 1180 1190 1200
CYEWARGMSF NRITDLTDVL EGSIVRTIIR LDEVLRECRG AARVVGDSSM YTKMEECQNL
1210
IRRNIVFCPS LYM