O59791

PR
Gene name
SRR (SPCC320.14, SPCC330.15c)
Protein name
Serine racemase
Names
D-serine ammonia-lyase, D-serine dehydratase, L-serine ammonia-lyase, L-serine dehydratase
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC320.14
EC number
4.3.1.17: Ammonia-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for O59791

Entry ID Method Resolution Chain Position Source
1V71 X-ray 170 A A 1-323 PDB
1WTC X-ray 190 A A 1-323 PDB
2ZPU X-ray 170 A A 1-323 PDB
2ZR8 X-ray 220 A A 1-323 PDB
AF-O59791-F1 Predicted AlphaFoldDB

No variants for O59791

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O59791

No associated diseases with O59791

1 regional properties for O59791

Type Name Position InterPro Accession
domain Tryptophan synthase beta chain-like, PALP domain 23 - 309 IPR001926

Functions

Description
EC Number 4.3.1.17 Ammonia-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

8 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
D-serine ammonia-lyase activity Catalysis of the reaction: D-serine = pyruvate + NH3.
L-serine ammonia-lyase activity Catalysis of the reaction: L-serine = pyruvate + NH3.
magnesium ion binding Binding to a magnesium (Mg) ion.
protein homodimerization activity Binding to an identical protein to form a homodimer.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
serine racemase activity Catalysis of the synthesis of free D-serine from L-serine.
threonine racemase activity Catalysis of the reaction: L-threonine = D-threonine.

4 GO annotations of biological process

Name Definition
D-serine biosynthetic process The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine.
D-serine metabolic process The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid.
L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
pyruvate biosynthetic process The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDNLVLPTY DDVASASERI KKFANKTPVL TSSTVNKEFV AEVFFKCENF QKMGAFKFRG
70 80 90 100 110 120
ALNALSQLNE AQRKAGVLTF SSGNHAQAIA LSAKILGIPA KIIMPLDAPE AKVAATKGYG
130 140 150 160 170 180
GQVIMYDRYK DDREKMAKEI SEREGLTIIP PYDHPHVLAG QGTAAKELFE EVGPLDALFV
190 200 210 220 230 240
CLGGGGLLSG SALAARHFAP NCEVYGVEPE AGNDGQQSFR KGSIVHIDTP KTIADGAQTQ
250 260 270 280 290 300
HLGNYTFSII KEKVDDILTV SDEELIDCLK FYAARMKIVV EPTGCLSFAA ARAMKEKLKN
310 320
KRIGIIISGG NVDIERYAHF LSQ