O59725

PR
Gene name
mic60 (SPBC3E7.05c)
Protein name
MICOS complex subunit mic60
Names
Mitofilin
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC3E7.05c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

101-208 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O59725

Entry ID Method Resolution Chain Position Source
AF-O59725-F1 Predicted AlphaFoldDB

No variants for O59725

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O59725

No associated diseases with O59725

5 regional properties for O59725

Type Name Position InterPro Accession
domain TRAM domain 380 - 442 IPR002792
domain Elp3/MiaA/NifB-like, radical SAM core domain 149 - 369 IPR006638
domain Radical SAM 2 - 441 IPR007197
domain Methylthiotransferase, N-terminal 5 - 122 IPR013848
conserved_site Methylthiotransferase, conserved site 153 - 173 IPR020612

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
MICOS complex Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60.
mitochondrial crista junction A tubular structure of relatively uniform size that connects a mitochondrial crista to the mitochondrial inner boundary membrane.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
cristae formation The assembly of cristae, the inwards folds of the inner mitochondrial membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNRQLRTVKS CFSLQKTHQY RSFWIQSSLR ALPPDVKQNK TEPIPFVPKP EEGSSNKSNS
70 80 90 100 110 120
SKFRKRFLLL FLLGITGYSC SVVYCFKDPN FYDYFAEHTP FGKQVLYNVE QSWIGYKYLG
130 140 150 160 170 180
GNRIKVDDSS PKLKQNSNNI SKKQNSSRND DTKVKKDTTI ERPESLVVEI VDLPSEVTKD
190 200 210 220 230 240
TAEESVWKDI GLDQETGLSV TAIPIITETL DHAHEQEIKD QSLRFESSLN EANELHGKLS
250 260 270 280 290 300
KIQQEQEHLF EQRLREKVSE MESKLEALLI ARDEKWQSAF ESEKLRLQKL HEARLQQELF
310 320 330 340 350 360
KLASVFESKL KNELTEQAIT LEKLHLQSIK AQVEQERGSR LGRLQELRNS FQQLQELVRV
370 380 390 400 410 420
VLHENGRVTR LVDVSNTLDD LNKDMRFHKL SEVRQHVNTL KEATKDDELA ALASRVIEKI
430 440 450 460 470 480
VDSGPILDKE ELQTKFDTLS KEIYKTCFLT TESGFFGHLK SIILSQLPAA VFKSPDIVSV
490 500 510 520 530 540
KKTLEDARSH LLKDDLDGSV RALLSLSQWP RALSRDWINA CRRRMELQQA IEIIKASATL
SSQLEDAQQA