O59671

PR
Gene name
pof4 (ela1, SPBC29A3.08)
Protein name
Elongin-A
Names
Protein pof4
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC29A3.08
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

128-263 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O59671

Entry ID Method Resolution Chain Position Source
AF-O59671-F1 Predicted AlphaFoldDB

No variants for O59671

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O59671

No associated diseases with O59671

No regional properties for O59671

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O59671

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
elongin complex A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits.

2 GO annotations of molecular function

Name Definition
RNA polymerase II general transcription initiation factor activity A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription.
transcription elongation factor activity A molecular function that stimulates the elongation properties of the RNA polymerase during the elongation phase of transcription. A subclass of transcription elongation factors enable the transition from transcription initiation to elongation, while another class rescue stalled RNA polymerases.

2 GO annotations of biological process

Name Definition
transcription elongation by RNA polymerase II promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
transcription initiation at RNA polymerase II promoter A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYSLKDLCIQ VAQKHVHDID DIGDCPFELV KPILEKARPE HLIDLEEKSP HLKVDTQPLW
70 80 90 100 110 120
KDHVLRDFGL ELQKRTILNN IDDWRGLYGK LKKKRNAHYN VASAKLRSAY TKLEQSKQNK
130 140 150 160 170 180
RIVPLEREPR AARPPKRPRP MSNYCPKSSL MARAKSDFLK KASATRHIVS ATSSSRSFPQ
190 200 210 220 230 240
LHPLGRSSSN ATNTSTKRPL TSNTYPSIPL PPKSFTSQNF KSFNAVKTQP SSSSSPSISR
250 260
PTSFPMSFFP NPSRFSSQVP KRI