O59604

PR
Gene name
PH1941
Protein name
dTTP/UTP pyrophosphatase
Names
dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase
Species
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
KEGG Pathway
pho:PH1941
EC number
3.6.1.9: In phosphorus-containing anhydrides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-79 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O59604

Entry ID Method Resolution Chain Position Source
AF-O59604-F1 Predicted AlphaFoldDB

No variants for O59604

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O59604

1 associated diseases with O59604

[MIM: 261750]: Glycogen storage disease 9B (GSD9B)

A metabolic disorder characterized by hepatomegaly, only slightly elevated transaminases and plasma lipids, clinical improvement with increasing age, and remarkably no clinical muscle involvement. Biochemical observations suggest that this mild phenotype is caused by an incomplete holoenzyme that lacks the beta subunit, but that may possess residual activity. {ECO:0000269|PubMed:9402963}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID
  • A metabolic disorder characterized by hepatomegaly, only slightly elevated transaminases and plasma lipids, clinical improvement with increasing age, and remarkably no clinical muscle involvement. Biochemical observations suggest that this mild phenotype is caused by an incomplete holoenzyme that lacks the beta subunit, but that may possess residual activity. {ECO:0000269|PubMed:9402963}. Note=The disease is caused by variants affecting the gene represented in this entry.

2 regional properties for O59604

Type Name Position InterPro Accession
domain GH15-like domain 48 - 878 IPR011613
domain Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain 919 - 1077 IPR045583

Functions

Description
EC Number 3.6.1.9 In phosphorus-containing anhydrides
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
dTTP diphosphatase activity Catalysis of the reaction: dTTP + H2O = dTMP + H+ + diphosphate.
UTP diphosphatase activity Catalysis of the reaction: UTP + H2O = UMP + H+ + diphosphate.

1 GO annotations of biological process

Name Definition
nucleotide metabolic process The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMIILASSSP RRREILGRFF EIKVYPANVE ERSTVKDSRE KSLDIARKKA LSVSSKFPGA
70 80 90 100 110 120
TIVAADTMVI FRGKTLGKPR NAEEARKMLR ALSGNVHKVI TGYCIIHNGR IIEGVEETEV
130 140 150 160 170 180
KFREIGDELL EWYISTGEWK DKAGAYGIQG YASIFVEWIK GDYYNVVGLP IKVVVELTKL
GFKPKR