O59357
Gene name |
truB |
Protein name |
Probable tRNA pseudouridine synthase B |
Names |
tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase |
Species |
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) |
KEGG Pathway |
pho:PH1644 |
EC number |
5.4.99.25: Transferring other groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O59357
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O59357-F1 | Predicted | AlphaFoldDB |
No variants for O59357
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O59357 | |||||
No associated diseases with O59357
6 regional properties for O59357
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PUA domain | 251 - 325 | IPR002478 |
| domain | Pseudouridine synthase II, N-terminal | 67 - 118 | IPR002501-1 |
| domain | Pseudouridine synthase II, N-terminal | 120 - 180 | IPR002501-2 |
| domain | Uncharacterised domain CHP00451 | 240 - 320 | IPR004521 |
| domain | Dyskerin-like | 4 - 63 | IPR012960 |
| domain | tRNA pseudouridylate synthase B, C-terminal | 181 - 247 | IPR032819 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.4.99.25 | Transferring other groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| tRNA pseudouridine synthase activity | Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in a tRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARDEVRRML | PADIKREVLI | KDENAETNPK | WGFPPYERPI | ELHIQYGVIN | LDKPPGPTSH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EVVAWIKRIL | NLEKAGHGGT | LDPKVSGVLP | VALEKATRVV | QALLPAGKEY | VALMHLHGDV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PENKIIDVMK | EFEGEIIQRP | PLRSAVKRRL | RTRKVYYIEI | LEIDGRDVLF | KVGVEAGTYI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RSLIHHIGLA | LGVGAHMAEL | RRTRSGPFKE | DETLVTLHDL | VDYYHFWKED | GIEKYLRRAI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QPMEKAVEHL | PKIWIKDSAV | AAVAHGANLT | VPGIVKLNVG | IKRGDLVAIM | TLKDELVALG |
| 310 | 320 | 330 | |||
| KAMMTSQEMM | QRSKGIAVDV | EKVFMPRDWY | PKLW |