O59224
Gene name |
rrp42 |
Protein name |
Exosome complex component Rrp42 |
Names |
|
Species |
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) |
KEGG Pathway |
pho:PH1548 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O59224
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O59224-F1 | Predicted | AlphaFoldDB |
No variants for O59224
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O59224 | |||||
No associated diseases with O59224
13 regional properties for O59224
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | G-protein, beta subunit | 427 - 443 | IPR001632-1 |
| domain | G-protein, beta subunit | 446 - 460 | IPR001632-2 |
| domain | G-protein, beta subunit | 483 - 500 | IPR001632-3 |
| repeat | WD40 repeat | 123 - 305 | IPR001680-1 |
| repeat | WD40 repeat | 299 - 374 | IPR001680-2 |
| repeat | WD40 repeat | 378 - 502 | IPR001680-3 |
| domain | NLE | 31 - 94 | IPR012972 |
| conserved_site | WD40 repeat, conserved site | 242 - 256 | IPR019775-1 |
| conserved_site | WD40 repeat, conserved site | 283 - 297 | IPR019775-2 |
| conserved_site | WD40 repeat, conserved site | 446 - 460 | IPR019775-3 |
| repeat | G-protein beta WD-40 repeat | 242 - 256 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 283 - 297 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 446 - 460 | IPR020472-3 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| exosome (RNase complex) | A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| RNA catabolic process | The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDNEIVAGI | MRDHIINLLK | EGKRIDDRGF | EDYRPIEIEV | GIIEKAEGSA | LVKLGSTQVL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VGIKTTLGEP | FPDTPNMGVM | TTNVELVPLA | SPTFEPGPPD | ERAIELARVT | DRGIRESRAL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NLEKMVIVPG | KIVRVVFIDV | HVLDHDGNLM | DAIGIASIAA | LLNAKVPKVE | YNEETGEVEI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LEEKEPLPVE | RIPIPVTFAK | IGNILVVDPS | LEEELVMDGR | LTVTTDETGH | ISAVQKGEGG |
| 250 | 260 | 270 | |||
| AFKLEEVMYA | VETAFKKAEE | IRKIVLEAIK | KSGE |