O59207
Gene name |
truD |
Protein name |
Probable tRNA pseudouridine synthase D |
Names |
tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D |
Species |
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) |
KEGG Pathway |
pho:PH1538 |
EC number |
5.4.99.27: Transferring other groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O59207
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O59207-F1 | Predicted | AlphaFoldDB |
No variants for O59207
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O59207 | |||||
No associated diseases with O59207
3 regional properties for O59207
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Translation elongation factor EFTs/EF1B, dimerisation | 71 - 275 | IPR014039 |
| conserved_site | Translation elongation factor Ts, conserved site | 12 - 27 | IPR018101-1 |
| conserved_site | Translation elongation factor Ts, conserved site | 75 - 85 | IPR018101-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.4.99.27 | Transferring other groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| tRNA pseudouridine synthase activity | Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in a tRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLEDPLRNLR | YLTSSPGIGG | KIKVYPEDFI | VKEVIPKSIF | RGGRCRIYLL | KKKNWETMAA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IKEIAKRIGI | HYSEIGFAGT | KDRHAVTYQY | ISICREVDLE | NVAIKDVTLR | FVGYGRPLKL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GLLLGNFFKI | RVRDTTPELL | PNILKEAKEK | GGFPNYFGIQ | RFGEKRSVNH | IVGKLLLLGK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YEEAAEVFLG | YPGNGMEGDE | ARKKFLETKN | VDLALEEFPK | FLRYERAMLY | KYRETGSWKR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SFLALPRPIL | RIFIHAFQSY | LFNLYISRRI | EEGFPLNEAL | PGDIVVQVKK | GIPLRDRTYR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VTESNLDFVN | EKIMQGEAMV | SGPIFGYSYR | RSHGIPGRLE | DEILEEAGVS | LENFKRLPKP |
| 370 | 380 | 390 | 400 | ||
| MREPGGRREL | LIKPRGFRYK | TEGRDVLFKF | FLPKGVYATS | VLREIIKPT |