O58822
Gene name |
infB (PH1095) |
Protein name |
Probable translation initiation factor IF-2 |
Names |
|
Species |
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) |
KEGG Pathway |
pho:PH1095 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O58822
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O58822-F1 | Predicted | AlphaFoldDB |
No variants for O58822
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O58822 | |||||
No associated diseases with O58822
15 regional properties for O58822
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Translational (tr)-type GTP-binding domain | 451 - 668 | IPR000795 |
| domain | Hint domain C-terminal | 427 - 472 | IPR003586 |
| domain | Hint domain N-terminal | 21 - 133 | IPR003587 |
| domain | Intein DOD homing endonuclease | 173 - 265 | IPR004042 |
| domain | Translation elongation factor EFTu-like, domain 2 | 694 - 772 | IPR004161 |
| domain | Homing endonuclease, LAGLIDADG | 221 - 290 | IPR004860 |
| domain | Small GTP-binding protein domain | 467 - 592 | IPR005225 |
| ptm | Intein N-terminal splicing region | 23 - 113 | IPR006141 |
| domain | Intein | 100 - 113 | IPR006142-1 |
| domain | Intein | 224 - 236 | IPR006142-2 |
| domain | Intein | 252 - 267 | IPR006142-3 |
| domain | Intein | 444 - 461 | IPR006142-4 |
| domain | Translation initiation factor IF- 2, domain 3 | 783 - 893 | IPR023115 |
| domain | Elongation factor Tu-type domain | 914 - 1000 | IPR029459 |
| domain | Intein C-terminal splicing region | 446 - 467 | IPR030934 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| intein-mediated protein splicing | The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues. |
| intron homing | Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSYVKRIRQP | IIAVLGHVDH | GKCLLPEERV | ILPDYGPITL | EELFNMTKET | VFKDEEKEVR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KLGIRMPVAG | VDGRVRLLEG | PYVWKVRYKG | KMLRVKLKDW | HSVAVTPEHP | FLTTRGWVRA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DQLKPGDYVA | VPKILPGKDD | KEKFLQYVHE | KLKGKVHIKL | PSSDEEWETF | FYFAGTIFGR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ENSVNPEGLT | HEVKALLELF | KVLFEYPREV | LRVLFMAPVR | YVANFLRGFF | DINGYVNGEE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LRVEVRGAPH | EVLEELSLIL | LRLGIVSKIY | PTSLAISGRR | NLELFRRYIG | FSEKQKAKEL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EGIIRRSENS | ESYPIFEELR | RIRLLFGFTR | AELSSTIPLY | SKYESKEAPS | YEILMKILNT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IEKGSKDLNK | KITILEGRVR | DHEYIEEFKR | EGLIKDGKLT | ELGKELLEVW | RNREFDSRDV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NYLRNIIENF | VFLPVEKIEE | FEYDGYVYDV | TTETHNFIAN | GILVHNTTLL | DKIRKTNVAA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KEAGGITQHI | GATEVPIDVV | KKIAGPLIKL | WKAEIRLPGL | LFIDTPGHEA | FTSLRARGGS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LADLAVLVID | VNEGFQPQTI | ESIEILRRYR | TPFVVAANKI | DRIRGWVIEE | DEPFLMNIKR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QDQRAIQELE | TKLWELIGKF | YEFGFQANRF | DRVQNFTREL | AIVPISAKYG | IGIAELLVLI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AGLSQKYLEE | KLKIEVEGPA | RGTILEVREE | PGLGHTIDVI | IYDGTLHKDD | TIVVGGKDKA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IVTKVRALLK | PKPLDEIRDP | RFRFDYVDEV | TAAAGVKIAA | PGLEEALAGS | PVIAAPTPED |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VERAKEEIMR | QIESVVISTD | KVGVIVKADT | LGSLEALSKE | LQEKEIPIRK | ADVGNISKTD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VMEALSVKEE | NPKYGVILGF | NVKVNEDAKE | VAKAKEVPIF | VGNIIYKLIE | DYEAWIKEEE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EKRKRELLAK | VTFPGVIKLY | PDERYVFRRS | NPAIVGIEVL | EGRIKPGVTL | IKQNGQKVGT |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| IRSIKSRDEF | LQEARKGQAV | AIAIEGAIVG | RHIHPGETLY | VDLSRDDAII | LLKHLRDVLE |
| 1030 | 1040 | ||||
| DTDIKALKMI | AQVKAKEDPF | WRAV |