O58816
Gene name |
metE |
Protein name |
Methionine synthase |
Names |
Homocysteine methyltransferase |
Species |
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) |
KEGG Pathway |
pho:PH1089 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O58816
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O58816-F1 | Predicted | AlphaFoldDB |
No variants for O58816
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O58816 | |||||
No associated diseases with O58816
1 regional properties for O58816
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cobalamin-independent methionine synthase MetE, C-terminal/archaeal | 6 - 317 | IPR002629 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity | Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| methionine biosynthetic process | The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. |
| methylation | The process in which a methyl group is covalently attached to a molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELPILPTSV | IGSYPKPRWL | LRMYRLRDLG | KIPEEDFKEA | VKDASVSVLR | EHERAGVDIP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WDGEMWRTEM | TEHFTAKIGG | FKFYGPVRVW | GNAYFNKAAA | VDKLEYKEPL | VLEEFLWVKK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NTTREVVKIP | ITGPYTIAEW | SFNEYYPDKE | SFIMDLAKII | NKELKMLENH | GALYIQLDEP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AMLNHPDEVP | LAVEAINKAV | KGIKIKVGLH | VCYSNYYLLA | DYFDEIRVTQ | FALEFANRQF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RDMDFLKKLS | NKELGFGVVD | VHNPRIESVE | EIVKAIKKVF | EYVEPELLYI | NPDCGMKLLD |
| 310 | 320 | 330 | |||
| RNIAYNKLVN | MVKATELVRK | ELEREGKKTT | EFRTLKDI |