O58698

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
KEGG Pathway
pho:PH0965
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

350-425 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for O58698

Entry ID Method Resolution Chain Position Source
1WKB X-ray 205 A A 1-810 PDB
1WZ2 X-ray 321 A A/B 1-967 PDB
AF-O58698-F1 Predicted AlphaFoldDB

No variants for O58698

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O58698

No associated diseases with O58698

3 regional properties for O58698

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 43 - 54 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 12 - 689 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 726 - 859 IPR013155

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAELNFKAIE EKWQKRWLEA KIFEPNIRDK PKEKKFYITV AFPYLSGHLH VGHARTYTIP
70 80 90 100 110 120
DVIARFKRMQ GYNVLFPMAW HITGSPIVGI AERIKNRDPK TIWIYRDVYK VPEEILWTFE
130 140 150 160 170 180
DPINIVKYFM KAAKETFIRA GFSVDWSREF YTTSLFPPFS KFIEWQFWKL KEKGYIVKGA
190 200 210 220 230 240
HRVRWDPVVG TPLGDHDLME GEDVPILDYI IIKFELRENG EVIYLPAATL RPETVYGVTN
250 260 270 280 290 300
MWVNPNATYV KAKVRRKDKE ETWIVSKEAA YKLSFQDREI EVIEEFKGEK LIGKYVRNPV
310 320 330 340 350 360
SGDEVIILPA EFVDPDNATG VVMSVPAHAP FDHVALEDLK RETEILEKYD IDPRIVENIT
370 380 390 400 410 420
YISLIKLEGY GDFPAVEEVN KLGIKSQKDK EKLEQATKTI YKAEYHKGIF KVPPYEGKPV
430 440 450 460 470 480
QEVKEAIAKE MLEKGIAEIM YEFAEKNVIS RFGNRAVIKI IHDQWFIDYG NPEWKEKARK
490 500 510 520 530 540
ALERMKILPE TRRAQFEAII DWLDKKACAR KIGLGTPLPW DPEWVIESLS DSTIYMAYYT
550 560 570 580 590 600
ISRHINKLRQ EGKLDPEKLT PEFFDYIFLE EFSEDKEKEL EKKTGIPAEI IHEMKEEFEY
610 620 630 640 650 660
WYPLDWRCSG KDLIPNHLTF FIFNHVAIFR EEHWPKGIAV NGFGTLEGQK MSKSKGNVLN
670 680 690 700 710 720
FIDAIEENGA DVVRLYIMSL AEHDSDFDWR RKEVGKLRKQ IERFYELISQ FAEYEVKGNV
730 740 750 760 770 780
ELKDIDRWML HRLNKAIKET TNALEEFRTR TAVQWAFYSI MNDLRWYLRR TEGRDDEAKR
790 800 810 820 830 840
YVLRTLADVW VRLMAPFTPH ICEELWEKLG GEGFVSLAKW PEPVEEWWNE TIEAEEEFIR
850 860 870 880 890 900
SVMEDIKEII EVAKIENAKR AYIYTAEDWK WKVAEVVSEK RDFKSSMEEL MKDSEIRKHG
910 920 930 940 950 960
KEVAKIVQKL IKERTFDVKR INEEKALREA KEFMEKELGI EIIINPTEDK GGKKKQAMPL
KPAIFIE