O58430

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
KEGG Pathway
pho:PH0699
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O58430

Entry ID Method Resolution Chain Position Source
AF-O58430-F1 Predicted AlphaFoldDB

No variants for O58430

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O58430

No associated diseases with O58430

5 regional properties for O58430

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 288 - 491 IPR002314
domain Anticodon-binding 512 - 602 IPR004154
domain Aminoacyl-tRNA synthetase, class II 209 - 505 IPR006195
domain Threonyl-tRNA synthetase, editing domain, archaea 1 - 139 IPR015011
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 510 - 600 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRILLIHSDY IEYEVKDKAI KNPEPISEEE KKGRMDEVLV AFISVEKVDE TNPEEVVSKA
70 80 90 100 110 120
VEEIINVASQ VKAENVFVYP FAHLSSELAK PSVAQEILRK VYEGLKEKGY NVGKAPFGYY
130 140 150 160 170 180
KAFKISCKGH PLAELSRTII PEGAKEEEVP EALKKEETEL VSYWYILTPE GELIEVDKFD
190 200 210 220 230 240
FTGYENLRKF ANYEISKSRI AEKEPPHVKL MLEHELVDYE PGSDPGNLRY YPKGRLIKSL
250 260 270 280 290 300
LEQYVTEKVI EYGAMEVETP VMYDFEHPAL EKYLNRFPAR QYIVLSGDKK YFLRFAACFG
310 320 330 340 350 360
QFLISKDAVI SYRHLPLRMY ELTRYSFRRE KRGELSGLRR LRAFTMPDMH TLAKDLEQAK
370 380 390 400 410 420
DEFKKQFKLS MEVLKGVGLT PEDYEVAIRF TEDFWKENRD FIVELVKIIG KPVLIEMWKQ
430 440 450 460 470 480
RFFYFILKFE FNFVDNLDKA AALSTVQIDV ENAERFGIKY YDENGEEKYP LILHCSPSGA
490 500 510 520 530 540
IERVMYAILE KQAKLMQEGK KPMLPLWLSP IQVRVIPVSE EYLDYALYIA GKLEGARIRV
550 560 570 580 590 600
DVDDEDERLN KKIRRAEKEW IPYIVVVGAK EKESGTITVR RREDGKQYET RLEELIKEIK
610 620
EKVEGFPYKP RPLPLLLSKR PKFRG