O58192

PR
Gene name
cheB
Protein name
Protein-glutamate methylesterase/protein-glutamine glutaminase
Names
Species
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
KEGG Pathway
pho:PH0483
EC number
3.1.1.61: Carboxylic ester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

86-185 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O58192

Entry ID Method Resolution Chain Position Source
AF-O58192-F1 Predicted AlphaFoldDB

No variants for O58192

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O58192

No associated diseases with O58192

2 regional properties for O58192

Type Name Position InterPro Accession
domain Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase 161 - 354 IPR000673
domain Signal transduction response regulator, receiver domain 8 - 127 IPR001789

Functions

Description
EC Number 3.1.1.61 Carboxylic ester hydrolases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
phosphorelay response regulator activity Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
protein-glutamate methylesterase activity Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol.
protein-glutamine glutaminase activity Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3.

3 GO annotations of biological process

Name Definition
chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
protein deamination The removal of an amino group from a protein amino acid.
protein demethylation The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPLMGRKIKV LVVDDSAFMR KVLKDIINSD PELEVCGEAR DGIEAIEMVQ KCRPDVVTLD
70 80 90 100 110 120
VEMPRMNGLD ALRVIMKRYP VPVIMISALT QEGADATIKA LEYGAIDFIP KPSSSISINM
130 140 150 160 170 180
KELKDEIIAK IKEAAKVPRR FLELRRIRLL RVQKAKKVKP SVPARIAVAI AASTGGPQSL
190 200 210 220 230 240
LKIFPKFPED LKAGILLVQH MPPGFTRSFA KRLDSVSKID VKEAEEGDVV EEGKAYVAPG
250 260 270 280 290 300
DYHMEVTLRA GKPVITLNKK PKIHGVRPAA DPMMITAAQV FGRRTVGVVM TGMGRDGAQG
310 320 330 340 350 360
IVEIKKKGGI TIAQDEKTSI IFGMPKAAIE TGMVDYVVPL EKIPETVVKA VEIIRGGGNL
GRHVTISR